The KL genetic polymorphisms Associated with type 2 diabetes Mellitus.

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Indian Journal of Clinical Biochemistry Pub Date : 2023-07-01 Epub Date: 2022-08-10 DOI:10.1007/s12291-022-01057-5

Hyun-Seok Jin, Dongju Jung

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引用次数: 0

Abstract

Growing number of research studies have shown that an anti-ageing gene Klotho (KL) is closely associated with Type 2 Diabetes Mellitus (T2DM). In this study, the association is genetically analyzed with single nucleotide polymorphism (SNP) of KL found in T2DM case of an Asian cohort. KL SNP information was obtained from a big database of the Korean Association Resource (KARE) from which 20 KL SNPs were available. Statistical analyses were conducted based on the 3 genetic models, such as additive, dominant, and recessive. Of the 20 KL SNPs, 12 SNPs were found to be significantly associated with T2DM in both of additive and dominant models. Odds ratios of the KL SNPs indicate increased susceptibility to T2DM in additive and dominant models. Significant association of KL with T2DM was further analyzed using imputed KL SNPs from HapMap reference data of the Eastern population. The statistically significant KL SNPs including the imputed SNPs distributed evenly over the KL gene area. The results in this study suggest klotho is a major player in the development of T2DM and the KL SNPs found in the case could be a risk marker of T2DM in the cohort.

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KL基因多态性与2型糖尿病的关系。

越来越多的研究表明，抗衰老基因Klotho（KL）与2型糖尿病（T2DM）密切相关。在这项研究中，将这种关联与亚洲队列的T2DM病例中发现的KL单核苷酸多态性（SNP）进行了遗传学分析。KL SNP信息是从韩国协会资源（KARE）的大数据库中获得的，从该数据库中可以获得20个KL SNPs。基于加性、显性和隐性三种遗传模型进行了统计分析。在20个KL SNPs中，发现12个SNPs在加性和显性模型中均与T2DM显著相关。KL SNPs的比值比表明在加性和显性模型中对T2DM的易感性增加。使用来自东部人群HapMap参考数据的估算KL SNPs进一步分析了KL与T2DM的显著相关性。具有统计学意义的KL SNPs，包括估算的SNPs，均匀分布在KL基因区域。这项研究的结果表明，klotho是T2DM发展的主要参与者，在该病例中发现的KL SNPs可能是队列中T2DM的风险标志物。

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来源期刊

Indian Journal of Clinical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

4.50

自引率

4.80%

发文量

期刊介绍： The primary mission of the journal is to promote improvement in the health and well-being of community through the development and practice of clinical biochemistry and dissemination of knowledge and recent advances in this discipline among professionals, diagnostics industry, government and non-government organizations. Indian Journal of Clinical Biochemistry (IJCB) publishes peer reviewed articles that contribute to the existing knowledge in all fields of Clinical biochemistry, either experimental or theoretical, particularly deal with the applications of biochemistry, molecular biology, genetics, biotechnology, and immunology to the diagnosis, treatment, monitoring and prevention of human diseases. The articles published also include those covering the analytical and molecular diagnostic techniques, instrumentation, data processing, quality assurance and accreditation aspects of the clinical investigations in which chemistry has played a major role, or laboratory animal studies with biochemical and clinical relevance.