The relationship of tumour-associated macrophages (CD68, CD163, CD11c) and cancer stem cell (CD44) markers with prognostic parameters in breast carcinomas.

IF 0.7 4区医学 Q4 PATHOLOGY

Polish Journal of Pathology Pub Date : 2022-01-01 DOI:10.5114/pjp.2022.125424

Suna Sari, Çiğdem Özdemir, Murat Çilekar

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引用次数: 0

Abstract

Introduction: In invasive breast cancer (IBC), tumour-associated macrophages and cancer stem cells in the tumour microenvironment are thought to be associated with poor prognosis, tumour growth, and metastasis.

Material and methods: In this study, we evaluated the relationship of CD68, CD163, CD11c, and CD44 expressions in the tumour microenvironment of IBC with prognostic parameters by immunohistochemical method.

Results: A correlation was found between high histological grade, oestrogen receptor/ progesterone receptor negativity, and high Ki-67 index in IBC, and the number of CD68-, CD163-, and CD11c-positive macrophages in the tumour microenvironment. In addition, in the tumour microenvironment, a correlation was found between IBC-specific subtypes and CD68, luminal A subtype relative to luminal B and CD163, HER2 score 3 cases, and CD11c-positive macrophage count. It was observed that CD44 expression in the tumour in IBC was not associated with the parameters examined. In addition, a high-level linear correlation was found between CD68- and CD163- and CD11c-positive macrophage counts. Tumour-associated macrophages in the tumour microenvironment in IBC may be a novel prognostic factor and an alternative avenue for targeted therapies.

Conclusions: The fact that CD44 positivity in the tumour is not associated with prognostic parameters will contribute to the literature in this direction.

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肿瘤相关巨噬细胞(CD68、CD163、CD11c)和肿瘤干细胞(CD44)标志物与乳腺癌预后参数的关系

在浸润性乳腺癌(IBC)中，肿瘤微环境中的肿瘤相关巨噬细胞和肿瘤干细胞被认为与预后不良、肿瘤生长和转移有关。材料与方法:本研究采用免疫组化方法评价IBC肿瘤微环境中CD68、CD163、CD11c和CD44的表达与预后参数的关系。结果:IBC高组织学分级、雌激素受体/孕激素受体阴性、Ki-67指数高与肿瘤微环境中CD68-、CD163-、cd11c阳性巨噬细胞数量呈正相关。此外，在肿瘤微环境中，ibc特异性亚型与CD68、腔内a亚型相对于腔内B和CD163、HER2评分3例和cd11c阳性巨噬细胞计数存在相关性。我们观察到，CD44在IBC肿瘤中的表达与所检查的参数无关。此外，CD68-、CD163-和cd11c阳性巨噬细胞计数之间存在高度线性相关。IBC肿瘤微环境中的肿瘤相关巨噬细胞可能是一种新的预后因素和靶向治疗的替代途径。结论:肿瘤中CD44阳性与预后参数无关的事实将有助于这一方向的文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polish Journal of Pathology PATHOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Polish Journal of Pathology is an official magazine of the Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology. For the last 18 years of its presence on the market it has published more than 360 original papers and scientific reports, often quoted in reviewed foreign magazines. A new extended Scientific Board of the quarterly magazine comprises people with recognised achievements in pathomorphology and biology, including molecular biology and cytogenetics, as well as clinical oncology. Polish scientists who are working abroad and are international authorities have also been invited. Apart from presenting scientific reports, the magazine will also play a didactic and training role.