Retinal Optical Coherence Tomography Angiography Findings following Retinoblastoma Treatment by Chemotherapy.

IF 1.2 Q3 OPHTHALMOLOGY
Hamid Riazi-Esfahani, Hadi Shamouli, Elias Khalili Pour, Kaveh Fadakar, Alireza Khodabandeh, Babak Masoomian, Vahid Hatami, Fariba Ghassemi
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引用次数: 0

Abstract

Purpose: To investigate the macular microvascular changes after different kinds of chemotherapy in patients with extramacular retinoblastoma (RB).

Methods: In this study, 28 eyes of 19 patients with bilateral RB treated with intravenous systemic chemotherapy (IVSC group) and 12 eyes of 12 patients with unilateral RB treated with intra-arterial chemotherapy (IAC group) were compared with 6 normal fellow eyes of 6 patients with unilateral RB treated with IVSC (IVSC fellow eye group), and 7 normal fellow eyes of 7 unilateral RB patients treated with IAC (IAC fellow eye group), as well as 12 age-matched normal eyes. Enhanced depth imaging optical coherence tomography measurements of central macular and subfoveal choroidal thickness (CMT and SFCT) as well as optical coherence tomography angiography measurements such as retinal superficial capillary density (SCD), deep capillary density (DCD), and choriocapillaris density were documented.

Results: Images of 2 eyes in the IVSC group and 8 eyes in the IAC group were excluded from the final image analysis due to severe retinal atrophy. Overall, 26 eyes with bilateral RB treated with IVSC and 4 eyes of 4 patients with unilateral RB treated with IAC were compared with the mentioned control groups. Best-corrected visual acuity was 1.03 logMAR in the IAC patients compared to 0.46 logMAR in the IVSC group at the time of imaging. While the CMT and SFCT were lower in the IAC group in comparison with the IAC fellow eye and normal groups (P < 0.05 for all), no remarkable difference was observed between the IVSC group and the control groups based on the mentioned parameters. Although the SCD showed no significant difference between the IVSC and control groups, this parameter was significantly lower in the eyes receiving IAC relative to the corresponding fellow eye group (P = 0.042) and normal control eyes (P = 0.047). The mean DCD was considerably lower in both the treatment groups compared to the control groups (P < 0.05 for all).

Conclusion: Our study showed a substantial decrease in SCD, DCD, CMT, and choroidal thickness in the IAC group, which may explain the lower visual outcome in this group.

Abstract Image

视网膜母细胞瘤化疗后视网膜光学相干断层血管造影的发现。
目的:探讨黄斑外视网膜母细胞瘤(RB)患者不同化疗方式对黄斑微血管的影响。方法:本研究将19例双侧RB患者的28只眼进行静脉全身化疗(IVSC组),12例单侧RB患者的12只眼进行动脉内化疗(IAC组),与6例单侧RB患者的6只眼进行IVSC同眼治疗(IVSC同眼组),7例单侧RB患者的7只眼进行IAC同眼治疗(IAC同眼组),以及12只年龄相匹配的正常眼进行比较。增强深度成像光学相干断层扫描测量中央黄斑和中央窝下脉络膜厚度(CMT和SFCT)以及光学相干断层扫描血管造影测量,如视网膜浅表毛细血管密度(SCD),深毛细血管密度(DCD)和绒毛膜毛细血管密度记录。结果:IVSC组2只眼和IAC组8只眼因严重的视网膜萎缩被排除在最终的图像分析之外。总的来说,与上述对照组相比,IVSC治疗的26只双侧RB和IAC治疗的4只单侧RB患者的4只眼睛。在成像时,IAC患者的最佳矫正视力为1.03 logMAR,而IVSC组为0.46 logMAR。虽然IAC组的CMT和SFCT低于IAC同眼组和正常组(P均< 0.05),但IVSC组与对照组在上述参数上无显著差异。虽然SCD在IVSC组和对照组之间没有显著差异,但该参数在接受IAC的眼睛中相对于相应的同组眼(P = 0.042)和正常对照眼(P = 0.047)明显降低。两组患者的平均DCD均显著低于对照组(P < 0.05)。结论:我们的研究显示,IAC组的SCD、DCD、CMT和脉络膜厚度显著降低,这可能解释了该组较低的视力结果。
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来源期刊
CiteScore
2.50
自引率
6.70%
发文量
45
审稿时长
8 weeks
期刊介绍: Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.
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