Immunotherapy for older patients with cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-01 Epub Date: 2023-01-20 DOI:10.1097/SPC.0000000000000637

Tatianny P Araujo Vargas, Abdullah Al-Humiqani, Danilo Giffoni De Mello Morais Mata, Ines B Menjak

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引用次数: 1

Abstract

Purpose of the review: The aim of this review is to describe the clinical use and tolerability of immune checkpoint inhibitors in older adults with solid tumors, where there is an abundance of evidence with recent updates including subgroups of older patients.

Recent findings: Studies with updated analyses and subgroups of older patients show that in general older patients benefit as well as younger patients and tolerate immunotherapy very well. However, in some instances of combination therapies which may expose patients to more toxicity, the benefits are reduced, and careful selection of older patients, including adjunctive assessments such as geriatric assessment, can help to identify the appropriate treatment for an individual patient.

Summary: Older adults remain underrepresented in clinical trials, including those involving immunotherapy. Therefore, efforts must be made to include more older patients in trials and to assess real-world evidence to inform decision-making.

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癌症老年患者的免疫治疗。

综述的目的：本综述的目的是描述免疫检查点抑制剂在患有实体瘤的老年人中的临床应用和耐受性，其中有大量证据表明最近的更新，包括老年患者的亚组。最近的发现：对老年患者的最新分析和亚组的研究表明，一般来说，老年患者和年轻患者一样受益，对免疫疗法的耐受性很好。然而，在某些可能使患者暴露于更大毒性的联合疗法的情况下，益处会降低，仔细选择老年患者，包括辅助评估，如老年评估，可以帮助确定适合个体患者的治疗方法。摘要：老年人在临床试验中的代表性仍然不足，包括那些涉及免疫疗法的试验。因此，必须努力将更多的老年患者纳入试验，并评估现实世界的证据，为决策提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.