An in-silico Approach for Recognition of Long non-coding RNA-Associated Competing Endogenous RNA Axes in Prostate Cancer.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urology Journal Pub Date : 2024-02-28 DOI:10.22037/uj.v20i.7650

Mohammad Taheri, Arash Safarzadeh, Soudeh Ghafouri-Fard, Aria Baniahmad

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引用次数: 0

Abstract

Purpose: Prostate cancer is among the most central sources of cancer-related mortalities. In order to find novel candidates for therapeutic strategies in this kind of cancer, we developed an in-silico method for identification of competing endogenous RNA network.

Methods: According to the microarray data analyses between prostate tumor and normal specimens, we attained 1312 differentially expressed (DE)mRNAs, including 778 down-regulated DEmRNAs (such as CXCL13 and BMP5) and 584 up-regulated DEmRNAs (such as OR51E2 and LUZP2), 39 DElncRNAs, including 10 down-regulated DElncRNAs (such as UBXN10-AS1 and FENDRR) and 29 up-regulated DElncRNAs (such as PCA3 and LINC00992) and 10 DEmiRNAs, including 2 down-regulated DEmiRNAs (such as MIR675 and MIR1908) and 8 up-regulated DEmiRNAs (such as MIR6773 and MIR4683).

Results: We constructed the ceRNA network between these transcripts. We also evaluated the related signaling pathways and the significance of these RNAs in prediction of survival of patients with prostate cancer.

Conclusion: This study provides novel candidates for construction of specific treatment routes for prostate cancer.

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识别前列腺癌中与长非编码 RNA 相关的竞争性内源性 RNA Axes 的一种内嵌方法。

目的：前列腺癌是造成癌症相关死亡的最主要原因之一。为了找到治疗这类癌症的新候选策略，我们开发了一种用于识别竞争性内源性 RNA 网络的方法：根据前列腺肿瘤和正常标本的芯片数据分析，我们获得了 1312 个差异表达（DE）mRNA，包括 778 个下调的 DEmRNA（如 CXCL13 和 BMP5）和 584 个上调的 DEmRNA（如 OR51E2 和 LUZP2），39 个 DElncRNA、包括 10 个下调的 DElncRNA（如 UBXN10-AS1 和 FENDRR）和 29 个上调的 DElncRNA（如 PCA3 和 LINC00992）；10 个 DEmiRNA，包括 2 个下调的 DEmiRNA（如 MIR675 和 MIR1908）和 8 个上调的 DEmiRNA（如 MIR6773 和 MIR4683）。结果我们构建了这些转录本之间的 ceRNA 网络。我们还评估了相关信号通路以及这些 RNA 在预测前列腺癌患者生存率方面的意义：本研究为构建前列腺癌的特异性治疗路径提供了新的候选方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.