Emerging Strategies to Improve the Stability and Bioavailability of Insulin: An Update on Formulations and Delivery Approaches.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2023-01-01 DOI:10.2174/1567201820666221102094433

Pak Kheong Tan, Umah Rani Kuppusamy, Kek Heng Chua, Bavani Arumugam

引用次数: 6

Abstract

One of the primary goals of diabetes management is to maintain blood glucose levels within a normal range, and insulin plays a vital role in achieving this. All Type 1 DM patients and advanced Type 2 DM patients require insulin. Insulin is administered subcutaneously, which may cause patient discomfort from the use of needles. Therefore, developing alternative routes of insulin administration has always been a major focus of diabetes research. This review aims to provide an update on the insulin formulations and delivery routes as well as strategies used to improve its stability and bioavailability for the treatment of diabetes.

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提高胰岛素稳定性和生物利用度的新策略:配方和给药方法的最新进展。

糖尿病管理的主要目标之一是将血糖水平维持在正常范围内，胰岛素在实现这一目标方面起着至关重要的作用。所有1型糖尿病患者和晚期2型糖尿病患者都需要胰岛素。胰岛素是皮下注射，这可能会引起患者使用针头的不适。因此，开发胰岛素的替代给药途径一直是糖尿病研究的重点。这篇综述旨在提供最新的胰岛素配方和给药途径，以及用于提高其稳定性和生物利用度治疗糖尿病的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.