PD-L1: expression regulation.

IF 1.5 Q3 HEMATOLOGY
Yu-Jie Zhou, Guoli Li, Jiyin Wang, Mengyuan Liu, Zihan Wang, Yu Song, Xulong Zhang, Xi Wang
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引用次数: 1

Abstract

Programmed death-ligand 1 (PD-L1), expressed on the surface of tumor cells, can bind to programmed cell death-1 (PD-1) on T cells. The interaction of PD-1 and PD-L1 can inhibit T-cell responses by decreasing T-cell activity and accelerating their apoptosis. Various cancers express high levels of PD-L1 and exploit PD-L1/PD-1 signaling to evade T-cell immunity, and immunotherapies targeting the PD-1/PD-L1 axis have been shown to exert remarkable anti-tumor effects; however, not all tumor patients benefit from these therapies. Therefore, study of the mechanisms regulating PD-L1 expression are imperative. In this review, we explore regulation of PD-L1 expression in the contexts of gene transcription, signaling pathways, histone modification and remodeling, microRNAs, long noncoding RNAs, and post-translational modification. Current developments in studies of agents that block PD-L1 and correlations between immunotherapies targeting PD-1/PD-L1 and PD-L1 expression are also summarized. Our review will assist in understanding of PD-L1 expression regulation and discusses the implications of reported findings in cancer diagnosis and immunotherapy.

Abstract Image

Abstract Image

PD-L1:表达调控。
程序性死亡配体1 (Programmed death-ligand 1, PD-L1)表达于肿瘤细胞表面,可与T细胞上的程序性细胞死亡1 (Programmed cell death-1, PD-1)结合。PD-1和PD-L1的相互作用可以通过降低t细胞活性和加速t细胞凋亡来抑制t细胞反应。多种癌症高水平表达PD-L1并利用PD-L1/PD-1信号逃避t细胞免疫,针对PD-1/PD-L1轴的免疫疗法已被证明具有显著的抗肿瘤作用;然而,并不是所有的肿瘤患者都能从这些疗法中获益。因此,研究调节PD-L1表达的机制势在必行。在这篇综述中,我们探讨了PD-L1在基因转录、信号通路、组蛋白修饰和重塑、microrna、长链非编码rna和翻译后修饰等方面的表达调控。本文还总结了阻断PD-L1药物的最新研究进展,以及针对PD-1/PD-L1的免疫疗法与PD-L1表达之间的相关性。我们的综述将有助于理解PD-L1表达调控,并讨论已报道的发现在癌症诊断和免疫治疗中的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
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审稿时长
10 weeks
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