Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies.

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Elizabeth A Jacobsen, David J Jackson, Enrico Heffler, Sameer K Mathur, Albert J Bredenoord, Ian D Pavord, Praveen Akuthota, Florence Roufosse, Marc E Rothenberg
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引用次数: 55

Abstract

The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice and more recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlike mouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit.

嗜酸性粒细胞敲除人类:通过嗜酸性粒细胞导向的生物疗法揭示嗜酸性粒细胞的作用。
神秘的嗜酸性粒细胞已成为免疫系统的一个令人兴奋的组成部分,参与过多的体内平衡和炎症反应。通过实验系统在体内操纵嗜酸性粒细胞已经取得了实质性进展,最初是在小鼠身上,最近在人类身上。研究人员利用嗜酸性粒细胞敲除小鼠发现了嗜酸性粒细胞在基础和炎症过程以及保护性免疫中的重要作用。由于嗜酸性粒细胞在嗜酸性粒细胞相关疾病中的促炎作用,一系列抗嗜酸性粒细胞治疗药物已成为一类新的药物。这些药物,其显著消耗嗜酸性粒细胞,提供了一个宝贵的机会来表征嗜酸性粒细胞敲除人类的后果。在这里,我们比较地描述了小鼠和人类的嗜酸性粒细胞敲除。我们提出的观点是,人类嗜酸性粒细胞对多种疾病有负面影响,并且与小鼠嗜酸性粒细胞不同,在生理健康中尚未确定作用;因此,澄清嗜酸性粒细胞的所有作用仍然是一个持续的追求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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