Osteoporosis and Bone Marrow Adipose Tissue.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2023-02-01 DOI:10.1007/s11914-022-00768-1

Kerensa M Beekman, Gustavo Duque, Alessandro Corsi, Michaela Tencerova, Peter H Bisschop, Julien Paccou

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引用次数: 6

Abstract

Purpose of review: This review focuses on the recent findings regarding bone marrow adipose tissue (BMAT) concerning bone health. We summarize the variations in BMAT in relation to age, sex, and skeletal sites, and provide an update on noninvasive imaging techniques to quantify human BMAT. Next, we discuss the role of BMAT in patients with osteoporosis and interventions that affect BMAT.

Recent findings: There are wide individual variations with region-specific fluctuation and age- and gender-specific differences in BMAT content and composition. The Bone Marrow Adiposity Society (BMAS) recommendations aim to standardize imaging protocols to increase comparability across studies and sites. Water-fat imaging (WFI) seems an accurate and efficient alternative for spectroscopy (¹H-MRS). Most studies indicate that greater BMAT is associated with lower bone mineral density (BMD) and a higher prevalence of vertebral fractures. The proton density fat fraction (PDFF) and changes in lipid composition have been associated with an increased risk of fractures independently of BMD. Therefore, PDFF and lipid composition could potentially be future imaging biomarkers for assessing fracture risk. Evidence of the inhibitory effect of osteoporosis treatments on BMAT is still limited to a few randomized controlled trials. Moreover, results from the FRAME biopsy sub-study highlight contradictory findings on the effect of the sclerostin antibody romosozumab on BMAT. Further understanding of the role(s) of BMAT will provide insight into the pathogenesis of osteoporosis and may lead to targeted preventive and therapeutic strategies.

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骨质疏松症和骨髓脂肪组织。

综述目的:本文综述了近年来有关骨髓脂肪组织(BMAT)与骨骼健康的研究进展。我们总结了BMAT的变化与年龄、性别和骨骼部位的关系，并提供了一种新的无创成像技术来量化人类BMAT。接下来，我们讨论BMAT在骨质疏松症患者中的作用以及影响BMAT的干预措施。最近的研究发现:BMAT的含量和组成存在广泛的个体差异，具有区域特异性波动和年龄和性别特异性差异。骨髓肥胖协会(BMAS)的建议旨在标准化成像方案，以增加研究和地点之间的可比性。水脂肪成像(WFI)似乎是光谱(1H-MRS)的一种准确而有效的替代方法。大多数研究表明，较高的BMAT与较低的骨密度(BMD)和较高的椎体骨折发生率相关。质子密度脂肪分数(PDFF)和脂质组成的变化与骨折风险增加无关，与骨密度无关。因此，PDFF和脂质组成可能成为未来评估骨折风险的成像生物标志物。骨质疏松治疗对BMAT抑制作用的证据仍然局限于少数随机对照试验。此外，FRAME活检亚研究的结果强调了关于硬化蛋白抗体romosozumab对BMAT影响的矛盾发现。进一步了解BMAT的作用将有助于深入了解骨质疏松症的发病机制，并可能导致有针对性的预防和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.