A comparative study of retinal layer changes among patients with schizophrenia and healthy controls.

IF 3.8 4区 医学 Q1 Medicine
Abhilaksh Kango, Sandeep Grover, Vishali Gupta, Swapnajeet Sahoo, Ritu Nehra
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引用次数: 3

Abstract

Aim: This study aimed to evaluate the retinal nerve fibre layer changes among different group of patients with schizophrenia and compare it with healthy controls by using swept-source optical coherence tomography.

Methodology: Patients with first-episode schizophrenia (n = 21) in remission (n = 35) or with treatment-resistant schizophrenia (TRS) (n = 35) and 36 healthy controls were evaluated for retinal thickness.

Results: Patients with psychotic illnesses had significantly lower sub-foveal choroidal thickness (effect size 0.84-0.86), when compared to the healthy controls. When patients with first-episode schizophrenia were compared with patients with TRS, TRS patients had significant lower sub-foveal choroidal thickness (left eye) when the various confounders (such as age, gender, duration of treatment, smoking, current medications, body mass index, waist circumference, blood pressure, fasting glucose, HbA1c, presence or absence of metabolic syndrome) were taken into account. When the patients with TRS were compared with healthy controls, initially significant differences were observed for the macular volume (left and right) and the ganglion cell thickness (right eye) but these differences disappeared after controlling for the various covariates.

Conclusions: Compared to healthy controls, patients with schizophrenia, psychotic illnesses have thinning of the retina, especially in the sub-foveal choroidal thickness.

精神分裂症患者与健康对照者视网膜层变化的比较研究。
目的:应用扫描源光学相干断层扫描技术,观察不同组精神分裂症患者视网膜神经纤维层的变化,并与健康对照进行比较。方法:对首发精神分裂症(n = 21)缓解期(n = 35)或难治性精神分裂症(TRS)患者(n = 35)和36名健康对照进行视网膜厚度评估。结果:与健康对照相比,精神病患者的中央凹下脉络膜厚度显著降低(效应值0.84-0.86)。当将首发精神分裂症患者与TRS患者进行比较时,考虑到各种混杂因素(如年龄、性别、治疗持续时间、吸烟、当前药物、体重指数、腰围、血压、空腹血糖、糖化血红蛋白、有无代谢综合征),TRS患者的中央窝下脉膜厚度(左眼)明显较低。当TRS患者与健康对照组比较时,最初在黄斑体积(左右)和神经节细胞厚度(右眼)上观察到显著差异,但在控制了各种协变量后,这些差异消失了。结论:与健康对照相比,精神分裂症、精神病患者视网膜变薄,特别是在中央凹下脉络膜厚度。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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