The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis.

IF 1.4 Q3 RHEUMATOLOGY
Reumatologia Pub Date : 2023-01-01 DOI:10.5114/reum/154905
Sousan Moudi, Behzad Heidari, Behnaz Yousefghahari, Reza Gholami, Hemmat Gholinia, Mansour Babaei
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引用次数: 2

Abstract

Introduction: Depression and anxiety share similar symptoms with rheumatoid arthritis (RA) and these conditions are often not diagnosed or overlooked in RA. This study aimed to determine the prevalence of depression/anxiety in RA and their correlation with RA activity.

Material and methods: Rheumatoid arthritis patients who presented at a rheumatology clinic were selected consecutively. The diagnosis of RA was confirmed by the ACR/EULAR criteria, disease activity was assessed by Disease Activity Score based on the 28-joint count (DAS28) and patients with DAS28 > 2.6 were considered to have active RA. The diagnosis of depression and anxiety was made by the Hospital Anxiety and Depression Scale (HADS). The Pearson test was used to determine the correlation between DAS28 and HADS scores.

Results: Two-hundred patients (female, 82%) with a mean age of 53.5 ±10.1 years and mean disease duration of 6.6 ±6.8 years were studied. Depression was diagnosed in 27 (13.5%) patients and anxiety in 38 (19%) patients. The DAS28 score correlated positively with depression (r = 0.173, p = 0.014) and anxiety score (r = 0.229, p = 0.001). In multiple logistic regression analysis after adjustment for all covariates, age < 40 years and female sex were independently associated with RA activity in patients with depression, with OR = 4.21 (p = 0.002) and OR = 3.56 (p = 0.028) respectively.

Conclusions: These findings indicate that depression and anxiety are prevalent in RA and correlate positively with active disease in particular in depressive female patients aged < 40 years.

类风湿关节炎患者抑郁、焦虑的患病率及其与疾病活动度的相关性
抑郁和焦虑与类风湿关节炎(RA)有相似的症状,这些症状在类风湿关节炎中经常未被诊断或忽视。本研究旨在确定RA中抑郁/焦虑的患病率及其与RA活动的相关性。材料和方法:连续选择在风湿病门诊就诊的类风湿关节炎患者。采用ACR/EULAR标准确诊RA,采用基于28关节计数的疾病活动性评分(DAS28)评估疾病活动性,DAS28 > 2.6为活动性RA。采用医院焦虑抑郁量表(HADS)进行抑郁和焦虑诊断。采用Pearson检验确定DAS28与HADS评分之间的相关性。结果:共纳入200例患者,女性82%,平均年龄53.5±10.1岁,平均病程6.6±6.8年。27例(13.5%)患者被诊断为抑郁症,38例(19%)患者被诊断为焦虑症。DAS28评分与抑郁(r = 0.173, p = 0.014)、焦虑(r = 0.229, p = 0.001)呈正相关。在对所有协变量进行校正后的多元logistic回归分析中,年龄< 40岁和女性与抑郁症患者RA活动独立相关,OR分别为4.21 (p = 0.002)和3.56 (p = 0.028)。结论:这些发现表明,抑郁和焦虑在RA中普遍存在,并且与活动性疾病呈正相关,特别是在年龄< 40岁的抑郁女性患者中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
自引率
0.00%
发文量
44
审稿时长
10 weeks
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