Stem cell-derived organoid models: defying the Hayflick limit

IF 39.1 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2023-01-25 DOI:10.1038/s41576-023-00577-x

Meritxell Huch

引用次数: 1

Abstract

In this Journal club, Meritxell Huch recalls a dogma postulated by Hayflick in 1961, that the capacity for propagating primary epithelial cells with normal ploidy is limited — a theory that persisted until the advent of organoid cultures.

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干细胞衍生的类器官模型：挑战海弗里克极限

在本期期刊俱乐部中，Meritxell Huch 回顾了海弗里克在 1961 年提出的一个理论，即繁殖具有正常倍性的原代上皮细胞的能力是有限的，这一理论一直持续到类器官培养物的出现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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