The Diagnostic Value of Circulating miR-29 Family for Digestive System Malignancies: A Meta-Analysis.

Laboratory medicine Pub Date : 2024-01-06 DOI:10.1093/labmed/lmad030

Shuhui Zou, Fei Chen, Liqin Zhang, Cong Liu, Huamin Chen

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Abstract

Objective: To evaluate the diagnostic value of circulating microRNA-29 (miR-29) in digestive system malignant neoplasms by meta-analysis.

Methods: We searched the PubMed, Embase, Cochrane Library, and Web of Science to collect studies, published through September 2022, on the diagnostic value of miR-29 in digestive system tumors.

Results: We included 7 studies in this meta-analysis, including colorectal cancer, esophageal squamous cell carcinomas, and cholangiocarcinoma. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.64 (95% CI, 0.53-0.74), 0.83 (0.60-0.94), 3.75 (1.42-9.91), 0.44 (0.31-0.61), and 8.63 (2.54-29.26), respectively. The area under the summary receiver operating characteristic curve was 0.75. The sensitivity of miR-29 derived from serum was higher than that of miR-29 derived from plasma for malignant digestive system tumors (0.71 vs 0.54; P = .04).

Conclusion: This meta-analysis suggests that the circulating miR-29 family has good diagnostic performance for digestive system malignant tumors, with moderate sensitivity and good specificity.

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循环 miR-29 家族对消化系统恶性肿瘤的诊断价值：一项元分析

目的通过荟萃分析评估循环microRNA-29（miR-29）在消化系统恶性肿瘤中的诊断价值：我们检索了 PubMed、Embase、Cochrane Library 和 Web of Science，收集了截至 2022 年 9 月发表的有关 miR-29 在消化系统肿瘤中诊断价值的研究：本次荟萃分析共纳入了7项研究，包括结直肠癌、食管鳞状细胞癌和胆管癌。汇总的敏感性、特异性、阳性似然比、阴性似然比和诊断几率比分别为0.64（95% CI，0.53-0.74）、0.83（0.60-0.94）、3.75（1.42-9.91）、0.44（0.31-0.61）和8.63（2.54-29.26）。接收者操作特征曲线下的面积为 0.75。血清中的 miR-29 对恶性消化系统肿瘤的敏感性高于血浆中的 miR-29（0.71 vs 0.54；P = .04）：这项荟萃分析表明，循环中的miR-29家族对消化系统恶性肿瘤具有良好的诊断性能，灵敏度适中，特异性良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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