Transcriptomics for radiation biodosimetry: progress and challenges.

IF 2.1 4区 医学 Q2 BIOLOGY
Sally A Amundson
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引用次数: 17

Abstract

Purpose: Transcriptomic-based approaches are being developed to meet the needs for large-scale radiation dose and injury assessment and provide population triage following a radiological or nuclear event. This review provides background and definition of the need for new biodosimetry approaches, and summarizes the major advances in this field. It discusses some of the major model systems used in gene signature development, and highlights some of the remaining challenges, including individual variation in gene expression, potential confounding factors, and accounting for the complexity of realistic exposure scenarios.

Conclusions: Transcriptomic approaches show great promise for both dose reconstruction and for prediction of individual radiological injury. However, further work will be needed to ensure that gene expression signatures will be robust and appropriate for their intended use in radiological or nuclear emergencies.

用于辐射生物测定的转录组学:进展与挑战。
目的:目前正在开发基于转录组的方法,以满足大规模辐射剂量和伤害评估的需要,并在辐射或核事件发生后对人群进行分流。本综述介绍了新的生物测定方法的背景和定义,并总结了该领域的主要进展。它讨论了基因特征开发中使用的一些主要模型系统,并强调了仍然存在的一些挑战,包括基因表达的个体差异、潜在的混杂因素以及考虑现实暴露情景的复杂性:转录组学方法在剂量重建和个体放射性损伤预测方面都大有可为。然而,要确保基因表达特征的稳健性并适合其在辐射或核紧急情况中的预期用途,还需要进一步的工作。
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来源期刊
CiteScore
5.00
自引率
11.50%
发文量
142
审稿时长
3 months
期刊介绍: The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.
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