Role of Inflammaging on the Reproductive Function and Pregnancy.

IF 8.4 2区 医学 Q1 ALLERGY
Alice Zavatta, Francesca Parisi, Chiara Mandò, Chiara Scaccabarozzi, Valeria M Savasi, Irene Cetin
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引用次数: 12

Abstract

During female lifetime and pregnancy, inflammation and cellular senescence are implicated in physiological processes, from ovulation and menstruation, to placental homeostasis and delivery. Several lifestyles, nutritional, and environmental insults, as well as long-lasting pregestational inflammatory diseases may lead to detrimental effects in promoting and sustaining a chronic excessive inflammatory response and inflammaging, which finally contribute to the decay of fertility and pregnancy outcome, with a negative effect on placental function, fetal development, and future health risk profile in the offspring. Maladaptation to pregnancy and obstetric disease may in turn increase maternal inflammaging in a feedback loop, speeding up aging processes and outbreak of chronic diseases. Maternal inflammaging may also impact, through transgenerational effects, on future adult health. Hence, efficacious interventions should be implemented by physicians and healthcare professionals involved in prevention activities to reduce the modifiable factors contributing to the inflammaging process in order to improve public health.

Abstract Image

Abstract Image

Abstract Image

炎症在生殖功能和妊娠中的作用。
在女性一生和怀孕期间,炎症和细胞衰老涉及从排卵和月经到胎盘稳态和分娩的生理过程。多种生活方式、营养和环境的损害,以及长期的妊娠期炎症性疾病,都可能对促进和维持慢性过度炎症反应和炎症产生不利影响,最终导致生育能力和妊娠结局的下降,对胎盘功能、胎儿发育和后代未来的健康风险状况产生负面影响。对妊娠和产科疾病的不适应反过来又可能在一个反馈循环中增加产妇炎症,加速衰老过程和慢性病的爆发。产妇炎症也可能通过跨代效应影响未来的成人健康。因此,参与预防活动的医生和保健专业人员应实施有效的干预措施,减少导致炎症过程的可改变因素,以改善公众健康。
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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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