Design and Development of Functionalized Single-walled Carbon Nanotube-ethosomes for Transdermal Delivery of Ketoprofen.

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Pharmazie Pub Date : 2023-05-01 DOI:10.1691/ph.2023.2572

J Xiaowei, Y Lijuan, L Yanling, L Qiuxiao, G Bohong

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引用次数: 0

Abstract

The purpose of this study was to combine carbon nanotube with ethosomes in order to obtain hybrid nanocarriers for transdermal delivery of ketoprofen (KP). KP-loaded functionalized single-walled carbon nanotube (f-SWCNTs) composite ethosomes (f-SWCNTs-KP-ES) were designed and were verified by a series of characterizations. The particle size of the preparation is less than 400 nm. DSC and XRD experiments showed that KP existed in an amorphous state after it was adsorbed and loaded on f-SWCNTs. TEM experiments showed that the structure of SWCNTs remained intact after oxidation and modification by PEI. FTIR results showed that PEI were successfully modified on the surface of SWCNT-COOH, and KP was successfully loaded on f-SWCNTs. In vitro release characteristics showed that the preparation had sustained release behavior and conformed to the first-order kinetic equation model. In addition, f-SWCNTs-KP-ES gel were prepared and in vitro skin permeation and in vivo pharmacokinetics were studied. The results showed that f-SWCNTs-KP-ES gel could enhance the skin permeation rate of KP and increase the drug retention of drugs in the skin. The characterization results consistently showed f-SWCNTs is a promising drug carrier. The hybrid nanocarrier prepared by the combination of f-SWCNTs and ethosomes can enhance the transdermal absorption of drugs and improve the bioavailability of drugs, which has a certain significance for the development of advanced hybrid nano-preparations.

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酮洛芬经皮给药功能化单壁碳纳米管酶体的设计与开发。

本研究的目的是将碳纳米管与酶质体结合，以获得酮洛芬(KP)透皮给药的混合纳米载体。设计了负载kp的功能化单壁碳纳米管(f-SWCNTs)复合质体(f-SWCNTs- kp - es)，并通过一系列表征进行了验证。制备的颗粒尺寸小于400nm。DSC和XRD实验表明，KP在f-SWCNTs上吸附和负载后以无定形存在。TEM实验表明，经PEI氧化和修饰后，SWCNTs的结构保持完整。FTIR结果表明，PEI成功修饰在swcnts - cooh表面，KP成功加载在f-SWCNTs表面。体外释放特性表明，该制剂具有缓释行为，符合一级动力学方程模型。此外，制备了f-SWCNTs-KP-ES凝胶，并研究了其体外皮肤渗透和体内药代动力学。结果表明，f-SWCNTs-KP-ES凝胶可以提高KP的皮肤渗透率，增加药物在皮肤中的药物滞留。表征结果一致表明f-SWCNTs是一种很有前景的药物载体。f-SWCNTs与质体结合制备的杂化纳米载体可增强药物的透皮吸收，提高药物的生物利用度，对开发先进的杂化纳米制剂具有一定的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmazie 医学-化学综合

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

1.2 months

期刊介绍： The journal DiePharmazie publishs reviews, experimental studies, letters to the editor, as well as book reviews. The following fields of pharmacy are covered: Pharmaceutical and medicinal chemistry; Pharmaceutical analysis and drug control; Pharmaceutical technolgy; Biopharmacy (biopharmaceutics, pharmacokinetics, biotransformation); Experimental and clinical pharmacology; Pharmaceutical biology (pharmacognosy); Clinical pharmacy; History of pharmacy.