Rett Syndrome Behaviour Questionnaire in Children and Adults With Rett Syndrome: Psychometric Characterization and Revised Factor Structure.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-01 DOI:10.1352/1944-7558-128.3.237

Lindsay M Oberman, Helen Leonard, Jenny Downs, Rina Cianfaglione, Michelle Stahlhut, Jane L Larsen, Katherine V Madden, Walter E Kaufmann

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引用次数: 0

Abstract

Rett syndrome (RTT) is a severe neurodevelopmental disorder associated with multiple neurobehavioral abnormalities. The Rett Syndrome Behaviour Questionnaire (RSBQ) was developed for pediatric RTT observational studies. Because its application has expanded to adult and interventional studies, we evaluated the RSBQ's psychometric properties in six pediatric (n = 323) and five adult (n = 309) datasets. Total and General Mood subscale scores had good reliability. Clinical severity had no influence on RSBQ scores. Exploratory and confirmatory factor analyses yielded 6 pediatric and 7 adult clinically relevant and psychometrically strong factors including the original Breathing Problems and Fear/Anxiety subscales and the novel Emotional and Disruptive Behavior subscale composed of items from the original General Mood and Nighttime Behaviours subscales. The present findings support additional evaluations and improvements of an important RTT behavioral measure.

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Rett综合征儿童和成人行为问卷:心理测量特征和修正的因素结构。

Rett综合征(RTT)是一种与多种神经行为异常相关的严重神经发育障碍。Rett综合征行为问卷(RSBQ)是为儿童RTT观察性研究而开发的。由于RSBQ的应用已扩展到成人和介入性研究，我们在6个儿科(n = 323)和5个成人(n = 309)数据集中评估了RSBQ的心理测量特性。总情绪量表和一般情绪量表得分具有良好的信度。临床严重程度对RSBQ评分无影响。探索性和验证性因素分析产生了6个儿科和7个成人临床相关和心理测量学上很强的因素，包括原始的呼吸问题和恐惧/焦虑子量表，以及由原始的一般情绪和夜间行为子量表中的项目组成的新的情绪和破坏性行为子量表。目前的研究结果支持额外的评估和改进一个重要的RTT行为测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.