Determinants of survival outcomes among esophageal cancer patients at a national referral hospital in Kenya

Q1 Medicine

Chronic Diseases and Translational Medicine Pub Date : 2022-11-20 DOI:10.1002/cdt3.52

Amsalu Degu, Peter N. Karimi, Sylvia A. Opanga, David G. Nyamu

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引用次数: 0

Abstract

Introduction

The overall 5-year survival rate for esophageal cancer patients in low- and middle-income countries was reported to be low, despite the availability of advanced treatments. Thus, this study aimed to assess determinants of survival outcomes among esophageal cancer patients in Kenya.

Methods

A retrospective cohort study was employed among 299 adult esophageal cancer patients. The data were collected using a data abstraction tool consisting of patients’ clinical characteristics and survival outcome measuring parameters. Statistical Package for the Social Sciences (SPSS) statistical software (version 20.0, IBM. USA) was used to analyze the data. The Kaplan–Meier and Cox regression analyses were used to determine the survival outcome and determinants of mortality, respectively.

Results

The mortality rate was 43.1%, and 11.1% of patients demonstrated distant metastases in the follow-up period. Despite treatment, 20.1% had progressed disease, and 13.0% did not respond to treatment. Radiotherapy (AHR: 3.3, 95% CI: 1.4−7.8, p = 0.007), chemotherapy (AHR: 3.9, 95% CI: 1.2−6.1, p = 0.020), and chemoradiation (AHR: 5.6, 95%CI: 1.6−10.2, p = 0.006) were the significant determinants of survival in advanced stage (III and and IV) patients.

Conclusions

There was a high mortality rate, disease progression, and nonresponse of esophageal cancer patients. Hence, it is essential to improve the survival of patients through early detection and timely initiation of the available treatment options.

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肯尼亚一家国家转诊医院食管癌患者生存结果的决定因素

据报道，中低收入国家食管癌患者的总体5年生存率很低，尽管有先进的治疗方法。因此，本研究旨在评估肯尼亚食管癌患者生存结果的决定因素。方法对299例成年食管癌患者进行回顾性队列研究。使用数据抽象工具收集数据，包括患者的临床特征和生存结局测量参数。统计软件包的社会科学(SPSS)统计软件(版本20.0,IBM。采用美国)对数据进行分析。Kaplan-Meier和Cox回归分析分别用于确定生存结局和死亡决定因素。结果随访期间患者死亡率为43.1%，远处转移率为11.1%。尽管接受了治疗，20.1%的患者病情进展，13.0%的患者对治疗无反应。放疗(AHR: 3.3, 95%CI: 1.4 ~ 7.8, p = 0.007)、化疗(AHR: 3.9, 95%CI: 1.2 ~ 6.1, p = 0.020)和放化疗(AHR: 5.6, 95%CI: 1.6 ~ 10.2, p = 0.006)是晚期(III期和IV期)患者生存的重要决定因素。结论食管癌患者死亡率高、病情进展快、无应答。因此，通过早期发现和及时启动可用的治疗方案来提高患者的生存率至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.