Aerobic Training with Naringin Supplementation Improved Spatial Cognition via H₂S Signaling Pathway in Alzheimer's Disease Model Rats.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-01 DOI:10.1080/0361073X.2022.2101303

Mojtaba Salehpour, Ghorbangol Ashabi, Majid Kashef, Elahe Sadat Marashi, Tayyebeh Ghasemi

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引用次数: 1

Abstract

Objectives: This study examined the effects of one-month naringin administration and exercise training on cognitive impairment and H₂S signaling pathway in an Amyloid β (Aβ)-injected rat.

Methods: Rats were divided into four groups: control group; rats underwent Aβ microinjection surgery, exercise group; rats underwent Aβ microinjection surgery and trained by treadmill for four weeks, naringin group; rats underwent Aβ microinjection surgery, and rats orally administrated 80 mg.kg^-1 naringin for four weeks, naringin+exercise group; rats underwent Aβ microinjection surgery and were trained by treadmill for four weeks, and also, rats orally administrated 80 mg.kg^-1 naringin for four weeks. After one month of treatment, spatial learning and memory were measured, and then hippocampi were sampled. S-adenosylmethionine (SAM), cystathionine-β-synthase (CBS), hydrogen sulfide (H₂S) levels, and neuronal death were detected in the hippocampi of rats.

Results: Naringin and exercise improved spatial learning (latency time, P < .001) and memory (P < .001) in the Morris Water Maze test in Aβ-injected rats compared with the control group. SAM (P < .01), CBS (P < .001), and H₂S (P < .01) levels are increased in the naringin+exercise group compared with the control group.

Conclusion: The result of this study supports the effect of exercise and/or naringin to improve cognitive dysfunction and cell death through the production of H₂S.

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有氧训练加柚皮苷通过H2S信号通路改善阿尔茨海默病模型大鼠的空间认知

目的:研究一个月柚皮苷和运动训练对β淀粉样蛋白(Aβ)注射大鼠认知功能障碍和H2S信号通路的影响。方法:将大鼠分为4组:对照组;大鼠进行Aβ显微注射手术，运动组;柚皮苷组大鼠进行Aβ显微注射手术和跑步机训练4周;大鼠进行Aβ显微注射手术，大鼠口服80 mg。Kg-1柚皮素治疗四周，柚皮素+运动组;大鼠进行Aβ显微注射手术并在跑步机上训练4周，大鼠口服80 mg。Kg-1进行为期四周的训练。治疗一个月后，测量空间学习和记忆，然后对海马体进行采样。检测大鼠海马组织中s -腺苷甲硫氨酸(SAM)、胱硫氨酸-β合酶(CBS)、硫化氢(H2S)水平及神经元死亡情况。结果:柚皮苷和运动可改善大鼠空间学习(潜伏期)、p2s (P)。结论:本研究结果支持运动和/或柚皮苷通过产生H2S改善认知功能障碍和细胞死亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.