Study on association of serum uric acid levels with bipolar disorder: systematic review and meta-analysis in Chinese patients.

IF 3.6 3区医学 Q1 PSYCHIATRY

Annals of General Psychiatry Pub Date : 2023-05-18 DOI:10.1186/s12991-023-00450-5

Haihan Chen, Fengli Sun, Weidong Jin

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Abstract

Background: The purine system represented by uric acid may be involved in the pathogenesis of bipolar disorder, This study intends to explore the association of serum uric acid levels with bipolar disorder in Chinese patients through meta-analysis.

Methods: Electronic databases, including PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI), searching from inception to December 2022. Randomized Controlled Trials that reported serum uric acid levels and bipolar disorder were included. Two investigators independently extracted data and RevMan5.4 and Stata14.2 were used for statistical analyses.

Results: Twenty-eight studies with 4482 bipolar disorder, 1568 depression, 785 schizophrenia, and 2876 healthy control subjects were included in this meta-analysis. The results of the meta-analysis showed that serum uric acid levels in the bipolar disorder group were significantly higher than those in depression [SMD 0.53 (0.37, 0.70), p < 0.00001], schizophrenia [SMD 0.27 (0.05, 0.49), p = 0.02] and healthy control group [SMD 0.87 (0.67, 1.06), p < 0.00001]. Subgroup-analysis showed that in Chinese people with bipolar disorder, uric acid levels of the manic episode were higher than the depressed episode [SMD 0.31 (0.22, 0.41), p < 0.00001].

Conclusion: Our results indicated a strong association between serum uric acid levels and bipolar disorder in Chinese patients, but further studies about whether uric acid levels can be a biomarker for bipolar disorder still need to investigate.

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血清尿酸水平与双相情感障碍的相关性研究:中国患者的系统回顾和荟萃分析。

背景:以尿酸为代表的嘌呤系统可能参与双相情感障碍的发病机制，本研究拟通过荟萃分析探讨中国患者血清尿酸水平与双相情感障碍的关系。方法:PubMed、Embase、Web of Science、中国知网(CNKI)等电子数据库，检索时间为建站至2022年12月。包括报告血清尿酸水平和双相情感障碍的随机对照试验。两名研究者独立提取数据，使用RevMan5.4和Stata14.2进行统计分析。结果:28项研究4482例双相情感障碍、1568例抑郁症、785例精神分裂症和2876例健康对照纳入本荟萃分析。荟萃分析结果显示，双相情感障碍组血清尿酸水平显著高于抑郁组[SMD = 0.53 (0.37, 0.70)， p]。结论:我们的研究结果表明，中国患者血清尿酸水平与双相情感障碍之间存在很强的相关性，但尿酸水平是否可以作为双相情感障碍的生物标志物仍需进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of General Psychiatry PSYCHIATRY-

CiteScore

6.60

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.