Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment.

Journal of Zhejiang University. Science. B Pub Date : 2023-04-15 DOI:10.1631/jzus.B2200576

Xuetao Zhao, Hongbing Lin, Tong Ding, Yawei Wang, Na Liu, Yuqin Shen

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Abstract

Periodontitis is a complex chronic inflammatory disease. The invasion of pathogens induces the inflammatory microenvironment in periodontitis. Cell behavior changes in response to changes in the microenvironment, which in turn alters the local inflammatory microenvironment of the periodontium through factors secreted by cells. It has been confirmed that periodontal ligament stem cells (PDLSCs) are vital in the development of periodontal disease. Moreover, PDLSCs are the most effective cell type to be used for periodontium regeneration. This review focuses on changes in PDLSCs, their basic biological behavior, osteogenic differentiation, and drug effects caused by the inflammatory microenvironment, to provide a better understanding of the influence of these factors on periodontal tissue homeostasis. In addition, we discuss the underlying mechanism in detail behind the reciprocal responses of PDLSCs that affect the microenvironment.

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与牙周韧带干细胞和炎症微环境变化相关的主要生物学机制综述。

牙周炎是一种复杂的慢性炎症性疾病。病原菌的侵袭可诱导牙周炎的炎症微环境。细胞行为随着微环境的变化而改变，而微环境的变化又通过细胞分泌的因子改变了牙周组织局部的炎症微环境。牙周韧带干细胞(PDLSCs)在牙周病的发展中起着至关重要的作用。此外，PDLSCs是用于牙周组织再生的最有效的细胞类型。本文就炎症微环境引起的PDLSCs的变化、基本生物学行为、成骨分化和药物作用等方面进行综述，以期更好地了解这些因素对牙周组织稳态的影响。此外，我们还详细讨论了PDLSCs影响微环境的相互反应背后的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Zhejiang University. Science. B

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