Lithium levels and lifestyle in patients with bipolar disorder: a new tool for self-management.

IF 2.8 2区医学 Q2 PSYCHIATRY

International Journal of Bipolar Disorders Pub Date : 2023-03-16 DOI:10.1186/s40345-023-00291-x

I Zorrilla, S Lopez-Zurbano, S Alberich, I Barbero, P Lopez-Pena, E García-Corres, J P Chart Pascual, J M Crespo, C de Dios, V Balanzá-Martínez, A Gonzalez-Pinto

{"title":"Lithium levels and lifestyle in patients with bipolar disorder: a new tool for self-management.","authors":"I Zorrilla, S Lopez-Zurbano, S Alberich, I Barbero, P Lopez-Pena, E García-Corres, J P Chart Pascual, J M Crespo, C de Dios, V Balanzá-Martínez, A Gonzalez-Pinto","doi":"10.1186/s40345-023-00291-x","DOIUrl":null,"url":null,"abstract":"Background: Patients should get actively involved in the management of their illness. The aim of this study was to assess the influence of lifestyle factors, including sleep, diet, and physical activity, on lithium levels in patients with bipolar disorder.Methods: A multicenter study was performed. In total, 157 lithium measurements were done biweekly in a sample of 65 patients (35 women) over 6 weeks. Lifestyle, based on total sleep hours and physical activity, was assessed by actigraphy. Diet was evaluated using the Mediterranean Lifestyle Index (Medlife).Results: 35.4% of patients had a normal weight. The mean Medlife score was 14.5 (± 2.5) (moderate-good adherence to Mediterranean diet). BMI, daily dose of lithium and intensity of physical activity had a combined effect on lithium levels, after adjustment for other variables. Patients who practiced intense physical exercise, who took lower doses and had a higher BMI exhibited lower levels of lithium.Conclusions: Higher physical activity and BMI contribute to lower lithium levels. Patients should be made aware of these relationships to improve their perception of control and self-management. Lifestyle-based interventions contribute to establishing a more personalized medicine.","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020397/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Bipolar Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40345-023-00291-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Patients should get actively involved in the management of their illness. The aim of this study was to assess the influence of lifestyle factors, including sleep, diet, and physical activity, on lithium levels in patients with bipolar disorder.

Methods: A multicenter study was performed. In total, 157 lithium measurements were done biweekly in a sample of 65 patients (35 women) over 6 weeks. Lifestyle, based on total sleep hours and physical activity, was assessed by actigraphy. Diet was evaluated using the Mediterranean Lifestyle Index (Medlife).

Results: 35.4% of patients had a normal weight. The mean Medlife score was 14.5 (± 2.5) (moderate-good adherence to Mediterranean diet). BMI, daily dose of lithium and intensity of physical activity had a combined effect on lithium levels, after adjustment for other variables. Patients who practiced intense physical exercise, who took lower doses and had a higher BMI exhibited lower levels of lithium.

Conclusions: Higher physical activity and BMI contribute to lower lithium levels. Patients should be made aware of these relationships to improve their perception of control and self-management. Lifestyle-based interventions contribute to establishing a more personalized medicine.

Abstract Image

查看原文本刊更多论文

双相情感障碍患者的锂水平和生活方式:一种自我管理的新工具。

背景:患者应该积极参与疾病的管理。本研究的目的是评估生活方式因素，包括睡眠、饮食和身体活动对双相情感障碍患者锂水平的影响。方法:采用多中心研究。总共有65名患者(35名女性)在6周内每两周进行157次锂测量。生活方式，基于总睡眠时间和身体活动，通过活动记录仪进行评估。饮食采用地中海生活方式指数(Medlife)进行评估。结果:35.4%的患者体重正常。平均Medlife评分为14.5(±2.5)(中等-良好的地中海饮食依从性)。在对其他变量进行调整后，BMI、锂的日剂量和体力活动强度对锂水平有综合影响。进行高强度体育锻炼、服用低剂量且BMI较高的患者表现出较低的锂含量。结论:较高的身体活动和BMI有助于降低锂含量。应使患者了解这些关系，以提高他们对控制和自我管理的认识。基于生活方式的干预有助于建立更加个性化的医疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Bipolar Disorders Medicine-Psychiatry and Mental Health

CiteScore

6.70

自引率

5.00%

发文量

审稿时长

13 weeks

期刊介绍： The International Journal of Bipolar Disorders is a peer-reviewed, open access online journal published under the SpringerOpen brand. It publishes contributions from the broad range of clinical, psychological and biological research in bipolar disorders. It is the official journal of the ECNP-ENBREC (European Network of Bipolar Research Expert Centres ) Bipolar Disorders Network, the International Group for the study of Lithium Treated Patients (IGSLi) and the Deutsche Gesellschaft für Bipolare Störungen (DGBS) and invites clinicians and researchers from around the globe to submit original research papers, short research communications, reviews, guidelines, case reports and letters to the editor that help to enhance understanding of bipolar disorders.