Sensitisation profile of Chinese allergic rhinitis patients and effectiveness of a joint allergy-ENT clinic

Q3 Medicine

Allergo Journal International Pub Date : 2022-07-07 DOI:10.1007/s40629-022-00218-5

Harris K. S. Hui, Tin Sum Li, Whitney L. W. Lo, Andy K. C. Kan, Shi Yeung Ho MBBS, FHKAM (ORL), Winnie Y. W. Yeung MBChB, FHKAM (Medicine), Jane C. Y. Wong MBBS, MRCP (UK), Valerie Chiang MBBS, Birgitta Y. H. Wong MBBS, FHKAM (ORL), Philip H. Li MBBS, FHKAM (Medicine)

{"title":"Sensitisation profile of Chinese allergic rhinitis patients and effectiveness of a joint allergy-ENT clinic","authors":"Harris K. S. Hui, Tin Sum Li, Whitney L. W. Lo, Andy K. C. Kan,  Shi Yeung Ho MBBS, FHKAM (ORL),  Winnie Y. W. Yeung MBChB, FHKAM (Medicine),  Jane C. Y. Wong MBBS, MRCP (UK),  Valerie Chiang MBBS,  Birgitta Y. H. Wong MBBS, FHKAM (ORL),  Philip H. Li MBBS, FHKAM (Medicine)","doi":"10.1007/s40629-022-00218-5","DOIUrl":null,"url":null,"abstract":"<div><h2>Summary</h2><div><h3>Purpose</h3><p>House dust mite (HDM) is the predominant cause of allergic rhinitis (AR) in Hong Kong but remains under-diagnosed and -treated. The association between patient-reported outcome measures (PROMs) and nasoendoscopy findings for AR have also not been investigated. This study investigated the demographics, sensitisation patterns, quality of life, use of sublingual immunotherapy and the association of PROMs and nasoendoscopy findings in AR patients through the first allergist–otorhinolaryngologists AR joint (ARJ) clinic in Hong Kong.</p><h3>Methods</h3><p>This single-centred, retrospective observational study was conducted between January 2021 and December 2021. Clinical data from AR patients attending the ARJ clinic were analysed to identify the prevalence of HDM allergens, change in PROMs and the association of PROMs with nasoendoscopy scores.</p><h3>Results</h3><p>The three most common sensitising HDM allergens were <i>Dermatophagoides pterynosinus </i>(94.4%), <i>Dermatophagoides farinae </i>(88.9%) and <i>Euroglyphus maynei </i>(88.9%). At the 13- to 32-week follow-up (median 28 weeks), patients who attended the ARJ clinic had significant improvement in Total Nasal Symptom Score (TNSS; <i>p</i> = 0.038). The visual analogue scale (VAS) was associated with nasoendoscopy score (<i>p</i> = 0.018). Patients using SLIT (sublingual immunotherapy) showed overall improvements in PROMs.</p><h3>Conclusion</h3><p>The ARJ clinic significantly improved AR symptoms. SLIT was effective and safe for patients who failed conventional treatments. VAS positively correlated with nasoendoscopy findings. Testing for<i> Dermatophagoides pterynosinus</i> as a single agent during skin testing was sufficient for the diagnosis of HDM AR and should be prioritized when resources are restricted. Further studies should be done to investigate the treatment outcome of AR patients and the effectiveness of SLIT in the Chinese population.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"32 2","pages":"29 - 37"},"PeriodicalIF":0.0000,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00218-5.pdf","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergo Journal International","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s40629-022-00218-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 3

Abstract

Summary

Purpose

House dust mite (HDM) is the predominant cause of allergic rhinitis (AR) in Hong Kong but remains under-diagnosed and -treated. The association between patient-reported outcome measures (PROMs) and nasoendoscopy findings for AR have also not been investigated. This study investigated the demographics, sensitisation patterns, quality of life, use of sublingual immunotherapy and the association of PROMs and nasoendoscopy findings in AR patients through the first allergist–otorhinolaryngologists AR joint (ARJ) clinic in Hong Kong.

Methods

This single-centred, retrospective observational study was conducted between January 2021 and December 2021. Clinical data from AR patients attending the ARJ clinic were analysed to identify the prevalence of HDM allergens, change in PROMs and the association of PROMs with nasoendoscopy scores.

Results

The three most common sensitising HDM allergens were Dermatophagoides pterynosinus (94.4%), Dermatophagoides farinae (88.9%) and Euroglyphus maynei (88.9%). At the 13- to 32-week follow-up (median 28 weeks), patients who attended the ARJ clinic had significant improvement in Total Nasal Symptom Score (TNSS; p = 0.038). The visual analogue scale (VAS) was associated with nasoendoscopy score (p = 0.018). Patients using SLIT (sublingual immunotherapy) showed overall improvements in PROMs.

Conclusion

The ARJ clinic significantly improved AR symptoms. SLIT was effective and safe for patients who failed conventional treatments. VAS positively correlated with nasoendoscopy findings. Testing for Dermatophagoides pterynosinus as a single agent during skin testing was sufficient for the diagnosis of HDM AR and should be prioritized when resources are restricted. Further studies should be done to investigate the treatment outcome of AR patients and the effectiveness of SLIT in the Chinese population.

Abstract Image

查看原文本刊更多论文

中国过敏性鼻炎患者的致敏特征及联合过敏性耳鼻喉科临床疗效

摘要目的屋尘螨（HDM）是香港变应性鼻炎（AR）的主要病因，但诊断和治疗仍然不足。患者报告的结果测量（PROMs）与AR鼻内镜检查结果之间的相关性也尚未调查。这项研究通过香港第一家过敏专科医生-耳鼻喉科医生AR联合诊所（ARJ）调查了AR患者的人口统计学、致敏模式、生活质量、舌下免疫疗法的使用以及PROM和鼻内镜检查结果的关联。方法这项单中心回顾性观察性研究于2021年1月至2021年12月进行。分析了ARJ诊所AR患者的临床数据，以确定HDM过敏原的患病率、PROM的变化以及PROM与鼻内镜评分的相关性。结果HDM最常见的三种致敏过敏原分别为：翼窦性皮炎（94.4%）、粉粒性皮炎（88.9%）和五月草（88.9% = 视觉模拟评分（VAS）与鼻内镜评分相关（p = 0.018）。使用SLIT（舌下免疫疗法）的患者PROM总体改善。结论ARJ临床显著改善了AR症状。SLIT对常规治疗失败的患者有效且安全。VAS与鼻内镜检查结果呈正相关。在皮肤测试过程中，作为单一试剂对翼性尘螨进行测试足以诊断HDM AR，在资源有限时应优先考虑。应进一步研究AR患者的治疗结果以及SLIT在中国人群中的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Allergo Journal International Medicine-Immunology and Allergy

CiteScore

4.60

自引率

0.00%

发文量

期刊介绍： Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies. All submissions are reviewed in single-blind fashion by at least two reviewers. Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.