Vitamin D Status in Palindromic Rheumatism: A Propensity Score Matching Analysis.

Laboratory medicine Pub Date : 2024-01-06 DOI:10.1093/labmed/lmad032

Alireza Khabbazi, Maryam Mahmoudi, Kamal Esalatmanesh, Masoomeh Asgari-Sabet, Azam Safary

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Abstract

Objective: To determine whether there is a correlation between vitamin D levels and palindromic rheumatism (PR) as an at-risk phenotype of rheumatoid arthritis (RA).

Methods: A total of 308 participants were enrolled in this cross-sectional study. We recorded their clinical characteristics and performed propensity-score matching (PSM). Serum 25(OH)D3 levels were determined via enzyme-linked immunosorbent assay.

Results: Our PSM resulted in 48 patients with PR and 96 matched control individuals. The multivariate regression analysis we performed after the PSM did not show a significant increase in PR risk in patients with vitamin D deficiency/insufficiency. There was no significant correlation between levels of 25(OH)D3 and frequency/duration of attacks, number of joints affected, and duration of symptoms before diagnosis (P ≥ .05). Mean (SD) serum levels of 25(OH)D3 in patients with and without progression to RA were 28.7 (15.9) ng/mL and 25.1 (11.4) ng/mL, respectively.

Conclusion: Based on the results, we found no clear association between vitamin D serum levels and the risk, severity, and rate of PR progressing into RA.

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风湿病患者的维生素 D 状态：倾向得分匹配分析

摘要确定维生素 D 水平与类风湿关节炎（RA）的高危表型--对折型风湿病（PR）之间是否存在相关性：这项横断面研究共招募了 308 名参与者。我们记录了他们的临床特征，并进行了倾向分数匹配（PSM）。通过酶联免疫吸附法测定血清 25(OH)D3 水平：我们的倾向分数匹配法得出了 48 名 PR 患者和 96 名匹配的对照组个体。我们在 PSM 后进行的多变量回归分析表明，维生素 D 缺乏/不足患者的 PR 风险并未显著增加。25(OH)D3 的水平与发作频率/持续时间、受影响关节的数量以及诊断前症状持续时间之间没有明显的相关性（P ≥ 0.05）。有RA进展和无RA进展的患者血清中25（OH）D3的平均（标度）水平分别为28.7（15.9）纳克/毫升和25.1（11.4）纳克/毫升：根据研究结果，我们发现维生素 D 血清水平与 PR 进展为 RA 的风险、严重程度和比率之间没有明显的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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