T, NK, then macrophages: Recent advances and challenges in adaptive immunotherapy from human pluripotent stem cells

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2023-03-01 DOI:10.1016/j.diff.2023.01.001

Su Hang , Nan Wang , Ryohichi Sugimura

引用次数: 3

Abstract

Adaptive cellular immunotherapy, especially chimeric antigen receptor-T (CAR-T) cell therapy, has advanced the treatment of hematological malignancy. However, major limitations still remain in the source of cells comes from the patients themselves. The use of human pluripotent stem cells to differentiate into immune cells, such as T cells, NK cells, and macrophages, then arm with chimeric antigen receptor (CAR) to enhance tumor killing has gained major attention. It is expected to solve the low number of immune cells recovery from patients, long waiting periods, and ethical issues(reprogramming somatic cells to produce induced pluripotent stem cells (iPS cells) avoids the ethical issues unique to embryonic stem cells (Lo and Parham, 2009). However, there are still major challenges to be further solved. This review summarizes the progress, challenges, and future direction in human pluripotent stem cell-based immunotherapy.

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T, NK，然后巨噬细胞:人类多能干细胞适应性免疫治疗的最新进展和挑战

适应性细胞免疫疗法，特别是嵌合抗原受体T（CAR-T）细胞疗法，已经推进了血液系统恶性肿瘤的治疗。然而，在细胞来源来自患者自身方面仍然存在重大限制。利用人类多能干细胞分化为免疫细胞，如T细胞、NK细胞和巨噬细胞，然后用嵌合抗原受体（CAR）武装以增强肿瘤杀伤已引起广泛关注。它有望解决从患者身上恢复的免疫细胞数量少、等待时间长和伦理问题（对体细胞进行重新编程以产生诱导多能干细胞（iPS细胞）避免了胚胎干细胞特有的伦理问题（Lo和Parham，2009）。然而，仍有重大挑战需要进一步解决。本文综述了基于人类多能干细胞的免疫治疗的进展、挑战和未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.