Youth-Onset Type 2 Diabetes: Burden of Complications and Socioeconomic Cost.

IF 5.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Diabetes Reports Pub Date : 2023-05-01 DOI:10.1007/s11892-023-01501-7

Isabella Marranzini Rodriquez, Katie L O'Sullivan

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引用次数: 3

Abstract

Purpose of review: With the rise in prevalence of youth-onset type 2 diabetes (T2DM), it is imperative to understand the clinical burden of the disease and the socioeconomic burden this disease imposes. We review the most recent data on youth-onset T2DM, including its pathophysiology, complications, and treatment. We also review existing data to determine the socioeconomic burden of youth-onset T2DM.

Recent findings: The incidence of youth-onset T2DM is rising, and significantly accelerated following the COVID-19 pandemic. Youth with T2DM are more frequently from families of racial/ethnic minorities and lower socioeconomic status. Youth-onset T2DM has more rapid disease progression compared to adult-onset type 2 diabetes. It results in earlier and more severe microvascular and macrovascular complications compared to both adult-onset T2DM and youth-onset type 1 diabetes (T1DM). While there is a lack of data describing the socioeconomic cost of youth-onset T2DM, based on extrapolation from analyses of the burden of T2DM in adults and T1DM in youth, we propose that youth-onset T2DM has higher direct and indirect costs than adult-onset T2DM. Youth-onset T2DM presents a significant clinical and socioeconomic burden due to its aggressive presentation and earlier appearance of complications. Additional research is needed regarding the cost of illness in this population.

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青少年2型糖尿病:并发症负担和社会经济成本

综述目的:随着青少年2型糖尿病(T2DM)患病率的上升，了解该疾病的临床负担和社会经济负担势在必行。我们回顾了关于青年发病T2DM的最新数据，包括其病理生理、并发症和治疗。我们还回顾了现有数据，以确定青年发病T2DM的社会经济负担。最新发现:青年发病T2DM的发病率正在上升，并在COVID-19大流行后显著加速。青少年2型糖尿病患者多来自少数民族和社会经济地位较低的家庭。与成人发病的2型糖尿病相比，青年发病的T2DM有更快的疾病进展。与成人发病的T2DM和青年发病的1型糖尿病(T1DM)相比，它会导致更早和更严重的微血管和大血管并发症。虽然缺乏描述青年发病T2DM的社会经济成本的数据，但基于对成人T2DM和青年T1DM负担的分析推断，我们认为青年发病T2DM的直接和间接成本高于成年发病T2DM。青年发病的2型糖尿病由于其侵袭性的表现和早期并发症的出现，呈现出显著的临床和社会经济负担。需要对这一人群的疾病成本进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Diabetes Reports 医学 -

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of diabetes epidemiology, pathophysiology, and management. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.