The gut microbiota, its relationship to the immune system, and possibilities of its modulation.

IF 0.5 4区 医学 Q4 MICROBIOLOGY
I Lukáčová, Ľ Ambro, K Dubayová, M Mareková
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引用次数: 0

Abstract

Research of the gut microbiota allows a better understanding of its composition and function and reveals the links between changes in the composition of bacteria and various intestinal but also systemic diseases. The gut microbiota performs several of important functions in the host body and influences many physiological processes. Gut bacteria synthesize many compounds needed for the proper function of the body (e.g., vitamins, short-chain fatty acids, and amino acids). They help maintain the integrity of the intestinal barrier and protect against pathogens. The gut microbiota plays a crucial role in the development and function of the immune system. Significant changes in the composition of the intestinal microbiota led to a dysbiotic state and the loss of its beneficial functions for humans. The review article summarizes the basic knowledge about the composition and function of the bacterial gut microbiota in healthy people, its role in the development of the immune system, and the mechanisms involved in maintaining homeostasis. It also presents current knowledge about the possibility of targeted modulation of the bacterial gut microbiota and faecal transplantation.

肠道菌群,它与免疫系统的关系,及其调节的可能性。
对肠道微生物群的研究可以更好地了解其组成和功能,并揭示细菌组成变化与各种肠道疾病以及全身性疾病之间的联系。肠道微生物群在宿主体内发挥着重要的功能,影响着许多生理过程。肠道细菌合成许多人体正常功能所需的化合物(如维生素、短链脂肪酸和氨基酸)。它们有助于维持肠道屏障的完整性并防止病原体。肠道菌群在免疫系统的发育和功能中起着至关重要的作用。肠道菌群组成的显著变化导致了一种生态失调状态,并丧失了对人类有益的功能。本文综述了健康人肠道菌群的组成和功能、在免疫系统发育中的作用以及维持体内平衡的机制等方面的基本知识。它也提出了目前的知识关于细菌肠道微生物群的靶向调节和粪便移植的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Epidemiologie Mikrobiologie Imunologie
Epidemiologie Mikrobiologie Imunologie Medicine-Immunology and Allergy
CiteScore
0.90
自引率
0.00%
发文量
20
期刊介绍: The journal publishes original papers, information from practice, reviews on epidemiological and microbiological subjects. Sufficient space is devoted to diagnostic methods from medical microbiology, parasitology, immunology, and to general aspects and discussions pertaining to preventive medicine. It also brings translations and book reviews useful for medical doctors and research workers and professionals in public health.
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