An Overview of Recently Published Patents on Pulmonary Drug Delivery Devices.

Suraj L Dongare, Minal R Narkhede
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Abstract

The pulmonary drug delivery system is a minimally invasive method of administering drugs with systemic and localised activity. Since 4000 BC, inhalation therapy has been known to the Indians. The most effective and suitable pulmonary drug delivery methods have been used for controlling diseases like asthma, chronic obstructive pulmonary disorder (COPD), TB(Tuberculosis), lung cancer, cystic fibrosis, and pulmonary hypertension. Examples of pulmonary medication delivery devices- Metered dose inhalers (MDIs), nebulizers, and dry powder inhalers (DPIs) in the latest patent 2022 that have undergone numerous advancements over the years have been focused on in this article. Some promising patented design advancements of nebulizers are humidifier breathing circuits to control liquid contamination, technologically advanced nebulizers to increase pressure detection and nebulizer disinfection system to decrease or eliminate contagions in expelled air are highlighted in this article. Some noticed formulation-related advancements for inhalational dry powder patented in the year 2022, are mentioned in this article. Development of heat-stable dry powder to solve instability of inhaled protein and peptide powder at high temperatures. The inability of dry powder inhaler devices to administer low doses is solved by designing an affordable and side effects-free inhaler. pMDI manufacturing process is simplified by manufacturing tablets to be administered in pMDI. An aid is developed to lessen the activation force and keep the dose count within budget. The patented advancement in the pulmonary drug delivery system can help in the improvement of patient compliance and drug delivery efficacy.

最近公布的肺部药物输送装置专利综述。
肺给药系统是一种微创给药方法,具有全身和局部活性。早在公元前4000年,印度人就已经知道了吸入疗法。最有效和最合适的肺给药方法已用于控制哮喘、慢性阻塞性肺疾病(COPD)、结核病(TB)、肺癌、囊性纤维化和肺动脉高压等疾病。肺部药物输送设备的例子-计量吸入器(MDIs),雾化器和干粉吸入器(dpi)在最新的专利2022中,多年来经历了许多进步,本文重点介绍了这些设备。本文重点介绍了雾化器的一些有前途的专利设计进步,包括控制液体污染的加湿器呼吸回路、技术先进的雾化器增加压力检测和雾化器消毒系统减少或消除排出空气中的传染。一些注意到的配方相关的进步,吸入干粉专利在2022年,在这篇文章中提到。研制热稳定干粉,解决吸入蛋白和肽粉在高温下的不稳定性。干粉吸入器装置无法管理低剂量是通过设计一个负担得起的和无副作用的吸入器解决。pMDI生产过程通过生产在pMDI中管理的片剂来简化。开发了一种辅助装置,以减少激活力并使剂量计数保持在预算范围内。该肺给药系统的专利进展有助于提高患者的依从性和给药效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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