Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery.

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-05-01 DOI:10.1515/jbcpp-2022-0244

Ali Azari, Vafa Baradaran Rahimi, Zahra Moravvej, Amir Ali Rahsepar, Majid Ghayour-Mobarhan, Maryam Salehi, Leila Bigdelu

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引用次数: 0

Abstract

Objectives: Cardiac surgeries initiate oxidative stress, increasing organ dysfunction development and mortality. The present study investigated the superoxide dismutase (SOD) activity, as an antioxidant enzyme, in patients undergoing coronary artery bypass (CABG) and heart valve replacement surgeries.

Methods: A prospective study was performed on patients with proven coronary artery disease (CAD) or valvular heart disease (VHD) candidates for on- or off-pump CABG and valve replacement surgery. Serum SOD activity was measured preoperatively, at 24 h postoperatively, and at the time of discharge. In addition, echocardiography was performed before surgery and at discharge.

Results: A total of 48, 51, and 47 patients were enrolled in the on-pump, off-pump CABG, and valve replacement groups, respectively. Baseline serum SOD activity showed no significant association with BMI, age, and blood pressure in either CAD or VHD patients. The SOD values decreased at the 24 h postoperative time and then increased at the time of discharge in all groups, except for a slight decrease in the on-pump group. The changes in serum SOD values were not significantly different for the three surgical groups.

Conclusions: The serum SOD activities fell significantly after CABG and valve replacement surgery. Further investigation is emphasized for the role of SOD in oxidative stress after cardiac surgery.

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无泵和无泵冠状动脉旁路移植术和瓣膜置换术的抗氧化活性。

目的:心脏手术引发氧化应激，增加器官功能障碍的发展和死亡率。本研究探讨了作为抗氧化酶的超氧化物歧化酶(SOD)在冠状动脉搭桥术(CABG)和心脏瓣膜置换术患者中的活性。方法:一项前瞻性研究对已证实的冠状动脉疾病(CAD)或瓣膜性心脏病(VHD)患者进行了开泵或不开泵CABG和瓣膜置换术。术前、术后24 h及出院时测定血清SOD活性。此外，术前和出院时进行超声心动图检查。结果:有泵、无泵CABG和瓣膜置换术组分别有48例、51例和47例患者入组。在CAD或VHD患者中，基线血清SOD活性显示与BMI、年龄和血压无显著关联。除无泵组SOD值略有下降外，其余各组术后24 h均呈下降趋势，出院时均呈上升趋势。三组患者血清SOD值变化无显著性差异。结论:CABG和瓣膜置换术后血清SOD活性明显下降。进一步研究SOD在心脏手术后氧化应激中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.