Kidney Xenotransplantation: Are We Ready for Prime Time?

IF 2.5 2区医学 Q2 UROLOGY & NEPHROLOGY

Current Urology Reports Pub Date : 2023-06-01 DOI:10.1007/s11934-023-01156-7

Rafael Miyashiro Nunes Dos Santos

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Abstract

Purpose of review: With the exponential increase in interest and great strides toward clinical application, many experts believe we are ready for kidney xenotransplant human trials. In this review, we will examine the obstacles overcome and those yet to be conquered, discussing the human trials performed and the questions they raised. Additionally, we will revisit overlooked aspects that may be crucial for improvements and suggest future approaches for xenotransplant research.

Recent findings: Improving survival in pig-to-non-human-primate models with the identification of an ideal immunosuppression regimen led to 3 cases of kidney xenotransplant in brain-dead humans with limited follow-up and a single clinical case of pig-to-human heart xenotransplant with 2-month survival. With limited human results and unlimited potential, xenotransplantation shines a beacon of hope for a brighter future. However, we must navigate through the complexities of balancing scientific progress and patient welfare, avoiding being blinded by xenotransplantation's unquestionable potential.

Abstract Image

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异种肾脏移植:我们准备好进入黄金时代了吗?

综述目的:随着人们对异种肾脏移植兴趣的指数增长和临床应用的巨大进步，许多专家认为我们已经准备好进行人体肾脏移植试验。在这篇综述中，我们将研究克服的障碍和尚未克服的障碍，讨论进行的人体试验和它们提出的问题。此外，我们将重新审视可能对改进至关重要的被忽视的方面，并提出异种移植研究的未来方法。最近的发现:通过确定一种理想的免疫抑制方案，提高猪到非人类灵长类动物模型的存活率，导致3例脑死亡人类肾脏异种移植，随访时间有限，1例猪到人类心脏异种移植临床病例存活2个月。异种移植对人类的影响有限，但潜力无限，它为更光明的未来点燃了希望的灯塔。然而，我们必须平衡科学进步和患者福利的复杂性，避免被异种移植毋庸置疑的潜力所蒙蔽。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Urology Reports UROLOGY & NEPHROLOGY-

CiteScore

4.60

自引率

3.80%

发文量

期刊介绍： This journal intends to review the most important, recently published findings in the field of urology. By providing clear, insightful, balanced contributions by international experts, the journal elucidates current and emerging approaches to the care and prevention of urologic diseases and conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as benign prostatic hyperplasia, erectile dysfunction, female urology, and kidney disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.