Mucoadhesive drug delivery systems: a promising non-invasive approach to bioavailability enhancement. Part I: biophysical considerations.

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Radha Kulkarni, Suraj Fanse, Diane J Burgess
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引用次数: 3

Abstract

Introduction: Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer for localized, prolonged, and/or targeted drug delivery. Over the past 4 decades, different sites have been explored for mucoadhesion including the nasal, oral, and vaginal cavities, the gastrointestinal tract and ocular tissues.

Areas covered: The present review aims to provide a comprehensive understanding of different aspects of MDDS development. Part I focuses on the anatomical and biological aspects of mucoadhesion, which include a detailed elucidation of the structure and anatomy of the mucosa, the properties of mucin, the different theories of mucoadhesion and evaluation techniques.

Expert opinion: The mucosal layer presents a unique opportunity for effective localization as well as systemic drug delivery via MDDS. Formulation of MDDS requires a thorough understanding of the anatomy of mucus tissue, the rate of mucus secretion and turnover, and the physicochemical properties of mucus. Further, the moisture content and the hydration of polymers are crucial for interaction with mucus. A confluence of different theories used to explain the mechanism of mucoadhesion is useful for understanding the mucoadhesion of different MDDS and their evaluation is subject to factors, such as the site of administration, type of dosage form, and duration of action. [Figure: see text].

黏附给药系统:一种有前途的非侵入性提高生物利用度的方法。第一部分:生物物理考虑。
简介:黏附给药系统(MDDS)是专门设计用于与粘膜层相互作用和结合,用于局部,长时间和/或靶向给药。在过去的40年里,人们探索了不同部位的粘膜粘连,包括鼻腔、口腔、阴道、胃肠道和眼部组织。涵盖范围:本检讨旨在全面了解千年发展目标发展的不同方面。第一部分侧重于粘膜粘附的解剖学和生物学方面,其中包括粘膜的结构和解剖学,粘蛋白的性质,粘膜粘附的不同理论和评估技术的详细说明。专家意见:粘膜层提供了一个独特的机会,可以通过MDDS有效定位和全身给药。制定MDDS需要彻底了解粘液组织的解剖结构,粘液分泌和周转的速度,以及粘液的理化性质。此外,聚合物的水分含量和水合作用对与黏液的相互作用至关重要。不同的理论用于解释黏附机制的融合有助于理解不同MDDS的黏附,其评估取决于诸如给药部位、剂型类型和作用时间等因素。[图:见正文]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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