Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations.

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Radha Kulkarni, Suraj Fanse, Diane J Burgess
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引用次数: 4

Abstract

Introduction: Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer of the epithelium for localized, prolonged, and/or targeted drug delivery. Over the past 4 decades, several dosage forms have been developed for localized as well as systemic drug delivery at different anatomical sites.

Areas covered: The objective of this review is to provide a detailed understanding of the different aspects of MDDS. Part II describes the origin and evolution of MDDS, followed by a discussion of the properties of mucoadhesive polymers. Finally, a synopsis of the different commercial aspects of MDDS, recent advances in the development of MDDS for biologics and COVID-19 as well as future perspectives are provided.

Expert opinion: A review of the past reports and recent advances reveal MDDS as highly versatile, biocompatible, and noninvasive drug delivery systems. The rise in the number of approved biologics, the introduction of newer highly efficient thiomers, as well as the recent advances in the field of nanotechnology have led to several excellent applications of MDDS, which are predicted to grow significantly in the future.

黏附给药系统:一种提高生物利用度的有前途的无创方法。第二部分:配方考虑。
简介:黏附给药系统(MDDS)是专门设计用于与上皮粘膜层相互作用和结合,用于局部,长时间和/或靶向给药。在过去的40年里,已经开发了几种剂型,用于不同解剖部位的局部和全身给药。涵盖的领域:本次审查的目的是提供对MDDS不同方面的详细了解。第二部分介绍了MDDS的起源和发展,然后讨论了粘接聚合物的性质。最后,简要介绍了MDDS的不同商业方面,生物制剂和COVID-19 MDDS开发的最新进展以及未来前景。专家意见:回顾过去的报告和最近的进展,MDDS是一种高度通用、生物相容性和无创的给药系统。批准的生物制剂数量的增加,新型高效硫聚体的引入,以及纳米技术领域的最新进展,导致了MDDS的几个出色应用,预计未来将显著增长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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