Ivabradine curbs isoproterenol-induced kidney fibrosis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-01 DOI:10.4149/gpb_2022057

Tomas Baka, Peter Stanko, Kristina Repova, Silvia Aziriova, Kristina Krajcirovicova, Andrej Barta, Stefan Zorad, Fedor Simko

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Abstract

This study investigated whether chronic isoproterenol administration could induce kidney alterations and whether ivabradine, a heart rate (HR)-reducing substance exerting cardiovascular protection, is able to attenuate potential kidney damage. Twenty-eight Wistar rats were divided into non-diseased controls, rats treated with ivabradine, rats treated with isoproterenol, and rats treated with isoproterenol plus ivabradine. Six weeks of isoproterenol administration was associated with decreased systolic blood pressure (SBP) (by 25%) and glomerular, tubulointerstitial and vascular/perivascular fibrosis due to enhanced type I collagen volume (7-, 8-, and 4-fold, respectively). Ivabradine reduced HR (by 15%), partly prevented SBP decline (by 10%) and site-specifically mitigated kidney fibrosis by decreasing type I collagen volume in all three sites investigated (by 69, 58, and 67%, respectively) and the ratio of type I collagen-to-type III collagen in glomerular and vascular/perivascular sites (by 79 and 73%, respectively). We conclude that ivabradine exerts protection against kidney remodelling in isoproterenol-induced kidney damage.

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伊伐布雷定抑制异丙肾上腺素诱导的肾纤维化。

本研究探讨慢性异丙肾上腺素是否会引起肾脏改变，以及伊伐布雷定是否能够减轻潜在的肾脏损害，伊伐布雷定是一种具有心血管保护作用的心率降低物质。28只Wistar大鼠分为未患病对照组、伊瓦布雷定组、异丙肾上腺素组和异丙肾上腺素+伊瓦布雷定组。异丙肾上腺素给药6周与收缩压(SBP)降低(25%)和肾小球、小管间质和血管/血管周围纤维化相关，原因是I型胶原体积增加(分别为7倍、8倍和4倍)。伊伐布雷定降低了HR(15%)，部分预防了SBP下降(10%)，并通过减少所有三个研究部位的I型胶原体积(分别减少69%、58%和67%)以及肾小球和血管/血管周围部位I型胶原与III型胶原的比例(分别减少79%和73%)，特异性地减轻了肾纤维化。我们得出结论，伊伐布雷定对异丙肾上腺素引起的肾损伤的肾脏重塑具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.