T-large granular lymphocytic leukemia.

IF 2.3 Q2 HEMATOLOGY
Sang Hyuk Park, Yoo Jin Lee, Youjin Kim, Hyun-Ki Kim, Ji-Hun Lim, Jae-Cheol Jo
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引用次数: 0

Abstract

T-cell large granular lymphocyte (T-LGL) leukemia is characterized by clonal expansion of cytotoxic T cells resulting in cytopenia. The proliferation of clonal LGLs is caused by prolonged antigenic stimulation, which leads to apoptotic dysregulation owing mainly to the constitutive activation of survival pathways, notably the JAK/STAT pathway. Understanding how leukemic T-LGL persists can aid in the development of future immunosuppressive therapies. In this review, we summarize the diagnosis and current standard of therapy for T-LGL leukemia, as well as recent advances in clinical trials.

Abstract Image

Abstract Image

t大颗粒淋巴细胞白血病。
T细胞大颗粒淋巴细胞(T- lgl)白血病的特点是细胞毒性T细胞克隆扩增导致细胞减少。克隆性LGLs的增殖是由长时间的抗原刺激引起的,这主要是由于生存通路的组成性激活,特别是JAK/STAT通路,导致凋亡失调。了解白血病T-LGL如何持续可以帮助开发未来的免疫抑制疗法。本文就T-LGL白血病的诊断、治疗标准以及临床研究的最新进展作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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