Potential Benefits of Aloe vera and Raphanus sativus var. longipinnatus Gel for Prevention of Radiation-Induced Dermatitis in Head and Neck Cancer Patients.

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY

Iranian Journal of Pharmaceutical Research Pub Date : 2022-12-01 DOI:10.5812/ijpr-132213

Sry Suryani Widjaja, Imam Bagus Sumantri, Rusdiana Rusdiana, Hendri Yo, Juli Jamnasi, Rudi Yo, Hendrik Kho, Vito Filbert Jayalie, Montesque Silalahi, Fauzie Siregar

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引用次数: 1

Abstract

Background: The main therapy for head and neck cancer is radiation, and one of the toxic effects of radiation is radiation dermatitis. Aloe vera is a species of succulent plant of the genus Aloe, widely used in cosmetic and skin care products, as well as daikon (Raphanus sativus var. longipinnatus), which is high in antioxidants.

Objectives: The present study aims to evaluate the potential benefits of Aloe vera and daikon gel combination in head and neck cancer patients to prevent radiation-induced dermatitis.

Methods: A cohort study was conducted with eligible subjects, all head and neck cancer patients receiving radiation therapy selected in consecutive sampling. Samples were divided into two groups; either received Aloe vera and daikon combination gel (study group) or baby oil (control induced dermatitis (RID) were observed.

Results: A total of 44 patients were grouped into intervention (Aloe vera-daikon gel) and control (baby oil) groups. After ten radiotherapies (RT) sessions, the intervention group had a lower percentage of grade 1 RID (35% vs. 91.7%, control: 65% grade 2 RID, P < 0.001). After 20 RT sessions, 40% had no dermatitis, while all patients had RID in the control group (P = 0.061). After 30 RT sessions, the intervention group had a lower RID grade overall (gr 0: 5%, gr 1: 85%, gr 2: 10%) compared to the control group (gr 1: 33.3%, gr 2: 54.3%, gr 3: 8.3%, P = 0.002). After 35 RT sessions, the intervention group also had a lower RID grade overall (gr 0: 5%, gr 1: 65%, gr 2: 20%, gr 3: 10%) compared to the control group (gr 1: 8.3%, gr 2: 37.5%, gr 3: 45.8%, gr 4: 8.3%, P < 0.001).

Conclusions: The combination of Aloe vera and daikon gel showed promising results in reducing the severity of radiation-induced dermatitis for head and neck cancer patients.

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芦荟和长鼻莴苣凝胶预防头颈癌患者放射性皮炎的潜在益处。

背景:头颈癌的主要治疗方法是放疗，而放疗的毒性作用之一是放射性皮炎。芦荟是芦荟属的一种多肉植物，广泛用于化妆品和护肤品，还有白萝卜(Raphanus sativus var. longipinnatus)，它富含抗氧化剂。目的:本研究旨在评估芦荟和白萝卜凝胶联合使用对头颈癌患者预防放射性皮炎的潜在益处。方法:采用队列研究方法，连续抽样选取所有接受放射治疗的头颈癌患者。样本分为两组;两组分别服用芦荟白萝卜联合凝胶(研究组)和婴儿油(对照组诱发性皮炎)。结果:44例患者分为干预组(芦荟凝胶)和对照组(婴儿油)。10次放疗(RT)后，干预组的1级RID发生率较低(35% vs. 91.7%，对照组:65%，P < 0.001)。20个RT疗程后，40%的患者无皮炎，而对照组所有患者均有RID (P = 0.061)。在30个RT疗程后，干预组的RID评分总体较低(gr 0: 5%， gr 1: 85%， gr 2: 10%)，而对照组(gr 1: 33.3%， gr 2: 54.3%， gr 3: 8.3%， P = 0.002)。经过35次RT治疗后，干预组的RID评分总体上也低于对照组(1:8.3%，2:37.5%，2:20%，3:10%)(1:8.3%，2:37.5%，3:45.8%，4:8.3%，P < 0.001)。结论:芦荟与白萝卜凝胶联合用药对降低头颈癌患者放射性皮炎的严重程度有较好的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Pharmaceutical Research 医学-药学

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

2 months

期刊介绍： The Iranian Journal of Pharmaceutical Research (IJPR) is a peer-reviewed multi-disciplinary pharmaceutical publication, scheduled to appear quarterly and serve as a means for scientific information exchange in the international pharmaceutical forum. Specific scientific topics of interest to the journal include, but are not limited to: pharmaceutics, industrial pharmacy, pharmacognosy, toxicology, medicinal chemistry, novel analytical methods for drug characterization, computational and modeling approaches to drug design, bio-medical experience, clinical investigation, rational drug prescribing, pharmacoeconomics, biotechnology, nanotechnology, biopharmaceutics and physical pharmacy.