The potential targets in immunotherapy of atherosclerosis.

IF 4.3 4区 医学 Q2 IMMUNOLOGY
Azin Aghamajidi, Melika Gorgani, Faezeh Shahba, Zahra Shafaghat, Nazanin Mojtabavi
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引用次数: 1

Abstract

Cardiovascular disease is the most common cause of death, which has the highest mortality rate worldwide. Although a diverse range of inflammatory diseases can affect the cardiovascular system, however, heart failure and stroke occur due to atherosclerosis. Atherosclerosis is a chronic autoinflammatory disease of small to large vessels in which different immune mediators are involved in lipid plaque formation and inflammatory vascular remodeling process. A better understanding of the pathophysiology of atherosclerosis may lead to uncovering immunomodulatory therapies. Despite present diagnostic and therapeutic methods, the lack of immunotherapy in the prevention and treatment of atherosclerosis is perceptible. In this review, we will discuss the promising immunological-based therapeutics and novel preventive approaches for atherosclerosis. This study could provide new insights into a better perception of targeted therapeutic pathways and biological therapies. [Formula: see text].

动脉粥样硬化免疫治疗的潜在靶点。
心血管疾病是最常见的死亡原因,是全世界死亡率最高的疾病。尽管多种炎症性疾病可影响心血管系统,但动脉粥样硬化导致心力衰竭和中风。动脉粥样硬化是一种小血管到大血管的慢性自身炎症性疾病,不同的免疫介质参与脂质斑块的形成和炎症性血管重构过程。更好地了解动脉粥样硬化的病理生理可能导致发现免疫调节疗法。尽管目前的诊断和治疗方法,免疫治疗在预防和治疗动脉粥样硬化方面的缺乏是显而易见的。在这篇综述中,我们将讨论基于免疫的治疗方法和新的预防动脉粥样硬化的方法。这项研究为更好地认识靶向治疗途径和生物治疗提供了新的见解。[公式:见正文]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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