Model of brain maintenance reveals specific change-change association between medial-temporal lobe integrity and episodic memory

IF 1.7 Q3 CLINICAL NEUROLOGY
Jarkko Johansson , Anders Wåhlin , Anders Lundquist , Andreas M. Brandmaier , Ulman Lindenberger , Lars Nyberg
{"title":"Model of brain maintenance reveals specific change-change association between medial-temporal lobe integrity and episodic memory","authors":"Jarkko Johansson ,&nbsp;Anders Wåhlin ,&nbsp;Anders Lundquist ,&nbsp;Andreas M. Brandmaier ,&nbsp;Ulman Lindenberger ,&nbsp;Lars Nyberg","doi":"10.1016/j.nbas.2021.100027","DOIUrl":null,"url":null,"abstract":"<div><p>Brain maintenance has been identified as a major determinant of successful memory aging. However, the extent to which brain maintenance in support of successful memory aging is specific to memory-related brain regions or forms part of a brain-wide phenomenon is unresolved. Here, we used longitudinal brain-wide gray matter MRI volumes in 262 healthy participants aged 55 to 80 years at baseline to investigate separable dimensions of brain atrophy, and explored the links of these dimensions to different dimensions of cognitive change. We statistically adjusted for common causes of change in both brain and cognition to reveal a potentially unique signature of brain maintenance related to successful memory aging. Critically, medial temporal lobe (MTL)/hippocampal change and episodic memory change were characterized by unique, residual variance beyond general factors of change in brain and cognition, and a reliable association between these two residualized variables was established (<em>r</em> = 0.36, p &lt; 0.01). The present study is the first to provide solid evidence for a specific association between changes in (MTL)/hippocampus and episodic memory in normal human aging. We conclude that hippocampus-specific brain maintenance relates to the specific preservation of episodic memory in old age, in line with the notion that brain maintenance operates at both general and domain-specific levels.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/a4/main.PMC9999442.pdf","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging brain","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589958921000232","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 7

Abstract

Brain maintenance has been identified as a major determinant of successful memory aging. However, the extent to which brain maintenance in support of successful memory aging is specific to memory-related brain regions or forms part of a brain-wide phenomenon is unresolved. Here, we used longitudinal brain-wide gray matter MRI volumes in 262 healthy participants aged 55 to 80 years at baseline to investigate separable dimensions of brain atrophy, and explored the links of these dimensions to different dimensions of cognitive change. We statistically adjusted for common causes of change in both brain and cognition to reveal a potentially unique signature of brain maintenance related to successful memory aging. Critically, medial temporal lobe (MTL)/hippocampal change and episodic memory change were characterized by unique, residual variance beyond general factors of change in brain and cognition, and a reliable association between these two residualized variables was established (r = 0.36, p < 0.01). The present study is the first to provide solid evidence for a specific association between changes in (MTL)/hippocampus and episodic memory in normal human aging. We conclude that hippocampus-specific brain maintenance relates to the specific preservation of episodic memory in old age, in line with the notion that brain maintenance operates at both general and domain-specific levels.

Abstract Image

Abstract Image

Abstract Image

脑维持模型揭示了中颞叶完整性与情景记忆之间的特定变化-变化关联
大脑维护已被确定为成功记忆老化的主要决定因素。然而,大脑维护在多大程度上支持成功的记忆老化是特定于记忆相关的大脑区域,还是形成了全脑现象的一部分,这一点尚未得到解决。在这里,我们使用262名年龄在55 - 80 岁的健康参与者的纵向脑灰质MRI体积来研究脑萎缩的可分离维度,并探索这些维度与认知变化的不同维度之间的联系。我们对大脑和认知变化的常见原因进行了统计调整,以揭示与成功的记忆衰老相关的大脑维护的潜在独特特征。重要的是,内侧颞叶(MTL)/海马变化和情景记忆变化具有独特的特征,残差超出了大脑和认知变化的一般因素,并且这两个残差变量之间建立了可靠的关联(r = 0.36,p < 0.01)。目前的研究首次为正常人类衰老过程中(MTL)/海马体的变化与情景记忆之间的特定关联提供了确凿的证据。我们得出结论,海马体特异性大脑维护与老年情景记忆的特定保存有关,这与大脑维护在一般和特定领域水平上运作的概念一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信