Clinical spectrum of elderly-onset inflammatory bowel disease in India.

IF 3.4 Q2 GASTROENTEROLOGY & HEPATOLOGY

Intestinal Research Pub Date : 2023-04-01 DOI:10.5217/ir.2021.00177

Yogesh Kumar Gupta, Arshdeep Singh, Vikram Narang, Vandana Midha, Ramit Mahajan, Varun Mehta, Dharmatma Singh, Namita Bansal, Madeline Vithya Barnaba Durairaj, Amit Kumar Dutta, Ajit Sood

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引用次数: 3

Abstract

Background/aims: Inflammatory bowel disease (IBD) is increasingly being recognized in elderly patients. Data on clinical spectrum of elderly-onset IBD patients is lacking from India.

Methods: A cross-sectional retrospective analysis of a prospectively maintained database of patients diagnosed with IBD was conducted at 2 centers in India. The clinical spectrum of elderly-onset IBD including demographic profile (age and sex), clinical presentation, disease characteristics (disease behavior and severity, extent of disease), and treatment were recorded and compared with adult-onset IBD.

Results: During the study period, 3,922 (3,172 ulcerative colitis [UC] and 750 Crohn's disease [CD]) patients with IBD were recorded in the database. A total of 186 patients (4.74%; 116 males [62.36%]) had elderly-onset IBD (69.35% UC and 30.64% CD). Diarrhea, blood in stools, nocturnal frequency and pain abdomen were the commonest presentations for UC, whereas pain abdomen, weight loss and diarrhea were the most frequent symptoms in CD. For both elderly onset UC and CD, majority of the patients had moderately severe disease. Left-sided colitis was the commonest disease location in UC. Isolated ileal disease and inflammatory behavior were the most common disease location and behavior, respectively in CD. 5-Aminosalicylates were the commonest prescribed drug for both elderly onset UC and CD. Thiopurines and biologics were used infrequently. Prevalence of colorectal cancer was higher in elderly onset IBD.

Conclusions: Elderly onset IBD is not uncommon in India. Both the elderly onset UC and CD were milder, with no significant differences in disease characteristics (disease extent, location and behavior) when compared to adult-onset IBD. Colorectal cancer was more common in elderly onset IBD.

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印度老年发炎性肠病的临床谱

背景/目的:炎症性肠病(IBD)越来越多地在老年患者中得到认可。印度缺乏老年IBD患者的临床谱数据。方法:对印度2个中心诊断为IBD的患者的前瞻性数据库进行横断面回顾性分析。记录老年发病IBD的临床谱，包括人口统计学特征(年龄和性别)、临床表现、疾病特征(疾病行为和严重程度、疾病程度)和治疗，并与成人发病IBD进行比较。结果:在研究期间，数据库中记录了3922例(3172例溃疡性结肠炎[UC]和750例克罗恩病[CD]) IBD患者。共186例(4.74%);116例男性(62.36%)为老年IBD，其中UC占69.35%，CD占30.64%。腹泻、便血、尿频和腹痛是UC最常见的表现，而腹痛、体重减轻和腹泻是CD最常见的症状。对于老年发病的UC和CD，大多数患者都有中度严重的疾病。左侧结肠炎是UC中最常见的疾病部位。孤立性回肠疾病和炎症行为分别是CD中最常见的疾病部位和行为。5-氨基水杨酸盐是老年发病UC和CD最常见的处方药，硫嘌呤和生物制剂的使用频率较低。老年IBD患者结直肠癌患病率较高。结论:老年IBD在印度并不罕见。老年起病的UC和CD都较轻，与成人起病的IBD相比，在疾病特征(疾病程度、部位和行为)上没有显著差异。结直肠癌在老年IBD发病中更为常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intestinal Research GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.40

自引率

10.20%

发文量

审稿时长

38 weeks

期刊介绍： Intestinal Research (Intest Res) is the joint official publication of the Asian Organization for Crohn''s and Colitis (AOCC), Chinese Society of IBD (CSIBD), Japanese Society for IBD (JSIBD), Korean Association for the Study of Intestinal Diseases (KASID), Taiwan Society of IBD (TSIBD) and Colitis Crohn''s Foundation (India) (CCF, india). The aim of the Journal is to provide broad and in-depth analysis of intestinal diseases, especially inflammatory bowel disease, which shows increasing tendency and significance. As a Journal specialized in clinical and translational research in gastroenterology, it encompasses multiple aspects of diseases originated from the small and large intestines. The Journal also seeks to propagate and exchange useful innovations, both in ideas and in practice, within the research community. As a mode of scholarly communication, it encourages scientific investigation through the rigorous peer-review system and constitutes a qualified and continual platform for sharing studies of researchers and practitioners. Specifically, the Journal presents up-to-date coverage of medical researches on the physiology, epidemiology, pathophysiology, clinical presentations, and therapeutic interventions of the intestinal diseases. General topics of interest include inflammatory bowel disease, colon and small intestine cancer or polyp, endoscopy, irritable bowel syndrome and other motility disorders, infectious enterocolitis, intestinal tuberculosis, and so forth. The Journal publishes diverse types of academic materials such as editorials, clinical and basic reviews, original articles, case reports, letters to the editor, brief communications, perspective, statement or commentary, and images that are useful to clinicians and researchers.