Assessing the impact of different neutron RBEs on the all solid cancer radiation risks obtained from the Japanese A-bomb survivors data.

IF 2.1 4区医学 Q2 BIOLOGY

International Journal of Radiation Biology Pub Date : 2023-01-01 DOI:10.1080/09553002.2022.2117871

Luana Hafner, Linda Walsh, Werner Rühm

{"title":"Assessing the impact of different neutron RBEs on the all solid cancer radiation risks obtained from the Japanese A-bomb survivors data.","authors":"Luana Hafner, Linda Walsh, Werner Rühm","doi":"10.1080/09553002.2022.2117871","DOIUrl":null,"url":null,"abstract":"Purpose: Development of a model characterizing risk variation with RBE to investigate how the incidence risk for all solid cancers combined varies with higher neutron RBEs and different organ dose types.Material and methods: The model is based on RERF data with separate neutron and gamma dose information.Results: For both additive and multiplicative linear excess risks per unit organ averaged dose, a reduction of 50% in the risk coefficient per weighted dose arises when a neutron RBE of 110 is used instead of 10. Considering risk per unit liver dose, this reduction occurs for an RBE of 130 and for risks per unit colon dose for an RBE of 190. The change in the shape of the dose response curve when using higher neutron RBEs is evaluated. The curvature changed and became significantly negative for males at an RBE of 140 for colon dose, 100 for liver dose and 80 for organ averaged dose. For females this is the case at an RBE of 110, 80 and 60, respectively.Conclusions: Uncertainties in neutron RBE values should be considered when radiation risks and the shape of dose responses are deduced from cancer risk data from the atomic bomb survivors.","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09553002.2022.2117871","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}

引用次数: 3

Abstract

Purpose: Development of a model characterizing risk variation with RBE to investigate how the incidence risk for all solid cancers combined varies with higher neutron RBEs and different organ dose types.

Material and methods: The model is based on RERF data with separate neutron and gamma dose information.

Results: For both additive and multiplicative linear excess risks per unit organ averaged dose, a reduction of 50% in the risk coefficient per weighted dose arises when a neutron RBE of 110 is used instead of 10. Considering risk per unit liver dose, this reduction occurs for an RBE of 130 and for risks per unit colon dose for an RBE of 190. The change in the shape of the dose response curve when using higher neutron RBEs is evaluated. The curvature changed and became significantly negative for males at an RBE of 140 for colon dose, 100 for liver dose and 80 for organ averaged dose. For females this is the case at an RBE of 110, 80 and 60, respectively.

Conclusions: Uncertainties in neutron RBE values should be considered when radiation risks and the shape of dose responses are deduced from cancer risk data from the atomic bomb survivors.

查看原文本刊更多论文

评估从日本原子弹幸存者数据中获得的不同中子RBEs对所有实体癌辐射风险的影响。

目的:建立一个表征RBE风险变化的模型，以研究高中子RBE和不同器官剂量类型对所有实体癌合并发病率的影响。材料和方法:该模型基于具有单独中子和伽马剂量信息的reff数据。结果:对于每单位器官平均剂量的可加性和可乘性线性过量风险，当中子RBE为110而不是10时，每加权剂量的风险系数降低了50%。考虑到每单位肝脏剂量的风险，RBE为130时发生这种降低，RBE为190时发生每单位结肠剂量的风险降低。对使用较高中子RBEs时剂量响应曲线形状的变化进行了评价。结肠剂量的RBE为140，肝脏剂量为100，器官平均剂量为80，男性的RBE曲线发生了变化，变为明显的负值。对于女性来说，RBE分别为110、80和60。结论:从原子弹爆炸幸存者的癌症风险数据推断辐射风险和剂量反应的形状时，应考虑中子RBE值的不确定性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Radiation Biology 医学-核科学技术

CiteScore

5.00

自引率

11.50%

发文量

142

审稿时长

3 months

期刊介绍： The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.