Tissue Homeostasis and Non-Homeostasis: From Cell Life Cycles to Organ States.

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Lucy Erin O'Brien
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引用次数: 2

Abstract

Although tissue homeostasis-the steady state-implies stability, our organs are in a state of continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically renew, to non-homeostatically resize upon altered functional demand, and to return to homeostasis after resizing or injury-in other words, to be dynamic. Here, I examine the basic unit of organ-scale cell dynamics: the cellular life cycle of birth, differentiation, and death. Focusing on epithelial organs, I discuss how spatial patterns and temporal kinetics of life cycle stages depend upon lineage organization and tissue architecture. I review how signaling between stages coordinates life cycle dynamics to enforce homeostasis, and I highlight how particular stages are transiently unbalanced to drive organ resizing or repair. Finally, I offer that considering organs as a collective of not cells but rather cell life cycles provides a powerful vantage for deciphering homeostatic and non-homeostatic tissue states.

组织稳态与非稳态:从细胞生命周期到器官状态。
虽然组织内稳态——稳定状态——意味着稳定,但我们的器官处于持续的、大规模的细胞流动状态。这种流动支撑着器官的内稳态更新能力、在功能需求改变时进行非内稳态调整的能力,以及在调整或损伤后恢复内稳态的能力——换句话说,是动态的。在这里,我研究了器官尺度细胞动力学的基本单位:细胞的出生、分化和死亡的生命周期。聚焦于上皮器官,我讨论了生命周期阶段的空间模式和时间动力学如何依赖于谱系组织和组织结构。我回顾了阶段之间的信号是如何协调生命周期动态以实现体内平衡的,并强调了特定阶段是如何短暂不平衡以驱动器官调整或修复的。最后,我提出,将器官视为细胞而不是细胞生命周期的集体,为破译体内平衡和非体内平衡的组织状态提供了强大的优势。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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