Synthesis and Characterization of Curcumin Incorporated Multi Component Nano-Scaffold with Enhanced Anti-bacterial and Wound Healing Properties.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2023-01-01 DOI:10.2174/1567201819666220414092342

Yi-Ying Wu, Ramya Kumar, Chi-Cheng Wong, Desu Naveen Kumar Reddy, Fu-Yung Huang

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引用次数: 3

Abstract

Background: Wound healing is one of the major challenges in chronic diseases; the current treatment options are less effective with undesirable side effects and are expensive. Extensive research is carried out to develop cost-effective, natural, biodegradable wound dressings that can reduce oxidative stress and inflammation and prevent bacterial infections. Curcumin has a plethora of therapeutic applications; however, its low solubility limits its clinical use.

Objective: In this study, curcumin nanoparticles (Cur NP) and curcumin-chitosan nanoparticles (CCNP) were incorporated into the chitosan collagen vanillin scaffold, characterized, and investigated their potential wound healing properties.

Methods: The nano-scaffolds were prepared by freeze-drying method and were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, nanoparticle tracking analysis, and scanning electron microscopy. The drug release, antioxidant, antibacterial, and wound healing properties were assessed by in vitro assays.

Results: Cur nano-scaffolds showed particle sizes of 195.9 nm and 110.6 nm for Cur NP+VC and CCNP+VC, respectively. The curcumin encapsulated in the Cur NP+VC and CC+VC nano-scaffolds showed a release profile of > 60% and an improved antioxidant activity of greater than 80%. The nanoscaffolds were antagonistic against Escherichia coli and Staphylococcus aureus and enhanced wound healing capacity of 85.62 % and 77.05% in the murine cell line.

Conclusion: The curcumin nano-scaffold is a biodegradable and effective drug delivery system for topical use that can act as an antioxidant, facilitate wound healing, as well as prevent bacterial infections.

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姜黄素复合多组分纳米支架的合成与表征

背景:伤口愈合是慢性疾病的主要挑战之一;目前的治疗方案效果较差，有不良副作用，而且价格昂贵。为了开发具有成本效益的、天然的、可生物降解的伤口敷料，人们进行了广泛的研究，以减少氧化应激和炎症，防止细菌感染。姜黄素有大量的治疗应用;然而，其低溶解度限制了其临床应用。目的:将姜黄素纳米颗粒(Cur NP)和姜黄素-壳聚糖纳米颗粒(CCNP)掺入壳聚糖胶原香兰素支架中，对其伤口愈合性能进行表征和研究。方法:采用冷冻干燥法制备纳米支架，采用傅里叶变换红外光谱、x射线衍射、纳米颗粒跟踪分析和扫描电镜对其进行表征。通过体外实验评估其药物释放、抗氧化、抗菌和伤口愈合性能。结果:Cur NP+VC和CCNP+VC纳米支架的粒径分别为195.9 nm和110.6 nm。包封在Cur NP+VC和CC+VC纳米支架中的姜黄素释放率> 60%，抗氧化活性提高80%以上。纳米支架对大肠埃希菌和金黄色葡萄球菌具有拮抗作用，使小鼠伤口愈合能力分别提高85.62%和77.05%。结论:姜黄素纳米支架具有抗氧化、促进伤口愈合、预防细菌感染等作用，是一种生物可降解的局部给药系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.