On the deformability of additivated phosphatidylcholine liposomes: Molecular dynamic regimes and membrane elasticity

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry and Physics of Lipids Pub Date : 2023-05-01 DOI:10.1016/j.chemphyslip.2023.105290

M.B. Marzola Coronel, C.C. Fraenza , E. Anoardo

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引用次数: 1

Abstract

Liposomes with enhanced elasticity have been proven to increase the efficiency of drug transport across the skin. The understanding of the background physicochemical processes driving the liposome viscoelastic properties is an essential feature for the design of effective formulations involving different lipids and additive molecules. In this work we use field-cycled nuclear magnetic resonance relaxometry to analyze both the mechanical properties of liposome membranes, and their relationship with the involved molecular dynamics. Different liposomal formulations were considered. We show a correlation between the molecular dynamical regime and mesoscopic physical parameters that define the expected deformability of the vesicles. Results strongly suggest that the purity of the used lipids may influence the elastic properties of the membranes in an appreciable way. Common features in the behaviour of the involved dynamic variables were identified by comparing formulations with surfactants of similar molecular weight.

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添加磷脂酰胆碱脂质体的可变形性:分子动力学机制和膜弹性

具有增强弹性的脂质体已被证明可以提高药物在皮肤上的运输效率。了解驱动脂质体粘弹性特性的背景物理化学过程是设计涉及不同脂质和添加剂分子的有效配方的基本特征。在这项工作中，我们使用场循环核磁共振弛豫仪来分析脂质体膜的力学性质，以及它们与所涉及的分子动力学的关系。考虑了不同的脂质体配方。我们展示了分子动力学机制和介观物理参数之间的相关性，这些参数定义了囊泡的预期可变形性。结果强烈表明，所用脂质的纯度可能会对膜的弹性性能产生可观的影响。通过比较具有相似分子量的表面活性剂的配方，确定了所涉及的动态变量行为的共同特征。

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来源期刊

Chemistry and Physics of Lipids 生物-生化与分子生物学

CiteScore

7.60

自引率

2.90%

发文量

审稿时长

40 days

期刊介绍： Chemistry and Physics of Lipids publishes research papers and review articles on chemical and physical aspects of lipids with primary emphasis on the relationship of these properties to biological functions and to biomedical applications. Accordingly, the journal covers: advances in synthetic and analytical lipid methodology; mass-spectrometry of lipids; chemical and physical characterisation of isolated structures; thermodynamics, phase behaviour, topology and dynamics of lipid assemblies; physicochemical studies into lipid-lipid and lipid-protein interactions in lipoproteins and in natural and model membranes; movement of lipids within, across and between membranes; intracellular lipid transfer; structure-function relationships and the nature of lipid-derived second messengers; chemical, physical and functional alterations of lipids induced by free radicals; enzymatic and non-enzymatic mechanisms of lipid peroxidation in cells, tissues, biofluids; oxidative lipidomics; and the role of lipids in the regulation of membrane-dependent biological processes.