{"title":"Calixarene: A Supramolecular Material for Treating Cancer.","authors":"Rui Li, Ning Liu, Rui Liu, Xin Jin, Zheng Li","doi":"10.2174/1567201820666230417084210","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer is a disease with a high mortality rate; therefore, research on new treatment strategies is essential. There has been increased interest in novel drug delivery systems (DDS) in recent years, such as calixarene, one of the most important principal molecules in supramolecular chemistry. Calixarene is a cyclic oligomer of phenolic units linked by methylene bridges that belongs to the third generation of supramolecular compounds. By modifying the phenolic hydroxyl end (lower edge) or the para-position, a wide range of calixarene derivatives can be obtained (upper edge). Drugs are combined with calixarenes to modify and have new properties, such as strong water solubility, the ability to bond with guest molecules, and excellent biocompatibility. In this review, we summarize the applications of calixarene in the construction of anticancer drug delivery systems and its application in clinical treatment and diagnosis. It provides theoretical support for the diagnosis and treatment of cancer in the future.</p>","PeriodicalId":10842,"journal":{"name":"Current drug delivery","volume":" ","pages":"184-192"},"PeriodicalIF":3.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current drug delivery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/1567201820666230417084210","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer is a disease with a high mortality rate; therefore, research on new treatment strategies is essential. There has been increased interest in novel drug delivery systems (DDS) in recent years, such as calixarene, one of the most important principal molecules in supramolecular chemistry. Calixarene is a cyclic oligomer of phenolic units linked by methylene bridges that belongs to the third generation of supramolecular compounds. By modifying the phenolic hydroxyl end (lower edge) or the para-position, a wide range of calixarene derivatives can be obtained (upper edge). Drugs are combined with calixarenes to modify and have new properties, such as strong water solubility, the ability to bond with guest molecules, and excellent biocompatibility. In this review, we summarize the applications of calixarene in the construction of anticancer drug delivery systems and its application in clinical treatment and diagnosis. It provides theoretical support for the diagnosis and treatment of cancer in the future.
期刊介绍：
Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves.
The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.
The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.
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