The role of sensory and sympathetic nerves in craniofacial bone regeneration

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2023-06-01 DOI:10.1016/j.npep.2023.102328

Freshet Assefa

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引用次数: 1

Abstract

Multiple factors regulate the regeneration of craniofacial bone defects. The nervous system is recognized as one of the critical regulators of bone mass, thereby suggesting a role for neuronal pathways in bone regeneration. However, in the context of craniofacial bone regeneration, little is known about the interplay between the nervous system and craniofacial bone. Sensory and sympathetic nerves interact with the bone through their neuropeptides, neurotransmitters, proteins, peptides, and amino acid derivates. The neuron-derived factors, such as semaphorin 3A (SEMA3A), substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP), possess a remarkable role in craniofacial regeneration. This review summarizes the roles of these factors and recently published factors such as secretoneurin (SN) and spexin (SPX) in the osteoblast and osteoclast differentiation, bone metabolism, growth, remodeling and discusses the novel application of nerve-based craniofacial bone regeneration. Moreover, the review will facilitate understanding the mechanism of action and provide potential treatment direction for the craniofacial bone defect.

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感觉神经和交感神经在颅面骨再生中的作用

多种因素调控颅面骨缺损的再生。神经系统被认为是骨量的关键调节因子之一，从而表明神经元通路在骨再生中的作用。然而，在颅面骨再生的背景下，人们对神经系统和颅面骨之间的相互作用知之甚少。感觉神经和交感神经通过其神经肽、神经递质、蛋白质、肽和氨基酸衍生物与骨骼相互作用。神经元衍生因子，如信号蛋白3A（SEMA3A）、P物质（SP）、降钙素基因相关肽（CGRP）、神经肽Y（NPY）和血管活性肠肽（VIP），在颅面再生中具有显著作用。本文综述了这些因子以及最近发表的分泌蛋白（SN）和spexin（SPX）等因子在成骨细胞和破骨细胞分化、骨代谢、生长和重塑中的作用，并讨论了基于神经的颅面骨再生的新应用。此外，该综述将有助于理解其作用机制，并为颅面骨缺损的治疗提供潜在的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.