SARS-CoV-2 infection and mortality in pediatric patients with hematological malignancies and solid tumors.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-01 DOI:10.1080/08880018.2022.2120937

João Eduardo Andrade Tavares de Aguiar, Marcos Antônio Lima Carvalho, Simone Santana Viana, Paulo Ricardo Martins-Filho, Rosana Cipolotti

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引用次数: 0

Abstract

The coronavirus disease 2019 (COVID-19) has emerged as a novel cause of mortality among children and adolescents in low- and middle-income settings. 1 In Brazil, deaths from COVID-19 among children and adolescents have exceeded the annual average of deaths from neoplasia, nervous system diseases, cardiac causes, and other vaccine-preventable diseases. 2 It was shown that the overall mortality rate associated with COVID-19 for children and adolescents aged 0–19 up to January 2022 was esti-mated at ∼ 4 deaths per 100,000 children and adolescents, with higher rates registered in the North and Northeast, 3 recognized as the poorest regions in the country. In addition, studies have suggested that immunocompromised children, including those with cancer, are at an increased risk of death from COVID-19 compared to hospitalized children without comorbidities 4 or the general pediatric population. 5 Here, we reported the prevalence of SARS-CoV-2 infection among hospitalized children and adolescents aged 0–21 with cancer and the occurrence of in-hospital deaths associated with COVID-19 in this population. This cross-sectional study was performed from April 2020 to September 2021 at the pediatric oncology center of a tertiary public hospital affiliated to the Brazilian Public Health System ( Sistema Único de Saúde - SUS) in Northeast Brazil. Due to the pandemic of COVID-19, the oncology center has established as a protocol the regular testing for SARS-CoV-2 by RT-PCR of all children undergoing cancer treatment, admitted to the hospital with cancer-related complications, or even with respiratory symptoms suggestive of COVID-19.

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小儿血液恶性肿瘤和实体瘤患者的SARS-CoV-2感染和死亡率

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.