Serum paraoxonase activity in familial hypercholesterolaemia.

Abstract

Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-bound esterase that protects low-density lipoprotein (LDL) and HDL from oxidative stress [1]. Low PON1 activity in the circulation is generally associated with increased risk for the development of atherosclerosis and cardiovascular disease [1]. While PON1 is a promiscuous enzyme, displaying esterase and lactonase activities