Dissecting dietary alkylresorcinols: a compile of their distribution, biosynthesis, extraction and functional properties.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Critical Reviews in Biotechnology Pub Date : 2024-06-01 Epub Date: 2023-05-08 DOI:10.1080/07388551.2023.2193860
Rehan M El-Shabasy, Mohamed A Farag
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引用次数: 0

Abstract

Alkylresorcinols (ARs) are natural bioactive ingredients produced by: bacteria, fungi, sponges, and higher plants, possessing a lipophilic polyphenol structure with a myriad of biological properties. Focusing on the importance of ARs, several analogs can be extracted from different natural resources. Interestingly, the composition of ARs is usually reflective of their source, with structural differences to exist among ARs isolated from different natural sources. The identified compounds from marine are distinguished by sulfur atom and disulfide bond, while the alkyl chain of bacterial homologs are recognized for their saturated fatty acid chains. ARs occurrence in fungi is still poorly documented however most of the isolated fungal molecules are characterized by a sugar unit attached to their alkylated side chains. The biosynthetic pathway of ARs is postulated via a type III polyketide synthase in which the fatty-acyl chain is elongated and cyclized to generate ARs. The structure-activity relationship (SAR) has gained an increasing interest to mediate for ARs biological activities as discussed herein for the first time from their different resources. ARs extraction procedures showed much progress compared to classical methods compiling organic solvents with supercritical extraction appearing as a potential technique for producing highly purified food-grade of AR homologs. The current review also presents on the rapid qualitative and quantitative determination of ARs to increase accessibility for screening cereals as potential sources of these bioactives.

剖析膳食中的烷基间苯二酚:其分布、生物合成、提取和功能特性汇编。
烷基间苯二酚(ARs)是由细菌、真菌、海绵和高等植物产生的天然生物活性成分,具有亲脂性多酚结构,具有多种生物特性。ARs 具有重要意义,可以从不同的自然资源中提取多种类似物。有趣的是,ARs 的组成通常反映了其来源,从不同天然资源中分离出来的 ARs 在结构上存在差异。从海洋中鉴定出的化合物是通过硫原子和二硫键来区分的,而细菌同源物的烷基链则是通过饱和脂肪酸链来识别的。真菌中出现 ARs 的记录还不多,但大多数分离出的真菌分子的特征是其烷基化侧链上附有一个糖单位。据推测,ARs 的生物合成途径是通过 III 型多酮合成酶,其中脂肪酰基链被拉长并环化生成 ARs。结构-活性关系(SAR)在促进 ARs 生物活性方面获得了越来越多的关注,本文首次从不同的资源中讨论了这一问题。与传统的有机溶剂萃取方法相比,ARs 的萃取程序有了很大的进步,超临界萃取技术已成为生产高纯度食品级 AR 同源物的潜在技术。本综述还介绍了 ARs 的快速定性和定量测定方法,以提高筛选谷物作为这些生物活性物质潜在来源的便利性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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