Chronic aphasias after left-hemisphere resective surgery

IF 2.1 2区心理学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Brain and Language Pub Date : 2023-04-01 DOI:10.1016/j.bandl.2023.105244

Greig I. de Zubicaray , Sonia L.E. Brownsett , David A. Copland , Kate Drummond , Rosalind L. Jeffree , Sarah Olson , Emma Murton , Benjamin Ong , Gail A. Robinson , Valeriya Tolkacheva , Katie L. McMahon

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引用次数: 1

Abstract

Surgical resection of brain tumours is associated with an increased risk of aphasia. However, relatively little is known about outcomes in the chronic phase (i.e., >6 months). Using voxel-based lesion symptom mapping (VLSM) in 46 patients, we investigated whether chronic language impairments are related to the location of surgical resection, residual tumour characteristics (e.g., peri-resection treatment effects, progressive infiltration, oedema) or both. Approximately 72% of patients scored below the cut-off for aphasia. Action naming and spoken sentence comprehension deficits were associated with lesions in the left anterior temporal and inferior parietal lobes, respectively. Voxel-wise analyses revealed significant associations between ventral language pathways and action naming deficits. Reading impairments were also associated with increasing disconnection of cerebellar pathways. The results indicate chronic post-surgical aphasias reflect a combination of resected tissue and tumour infiltration of language-related white matter tracts, implicating progressive disconnection as the critical mechanism of impairment.

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左半球切除术后的慢性失语症

脑瘤的外科切除与失语症的风险增加有关。然而，对慢性期（即>；6个月）的结果知之甚少。在46名患者中使用基于体素的病变症状映射（VLSM），我们研究了慢性语言障碍是否与手术切除的位置、残余肿瘤特征（例如，切除周围的治疗效果、进行性浸润、水肿）或两者有关。大约72%的患者失语症评分低于临界值。动作命名和口语句子理解缺陷分别与左颞前叶和顶叶下叶的病变有关。体素分析揭示了腹侧语言通路和动作命名缺陷之间的显著关联。阅读障碍也与小脑通路日益断开有关。结果表明，慢性术后失语症反映了切除的组织和肿瘤对语言相关白质束的浸润，表明进行性断开是损伤的关键机制。

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来源期刊

Brain and Language 医学-神经科学

CiteScore

4.50

自引率

8.00%

发文量

审稿时长

20.5 weeks

期刊介绍： An interdisciplinary journal, Brain and Language publishes articles that elucidate the complex relationships among language, brain, and behavior. The journal covers the large variety of modern techniques in cognitive neuroscience, including functional and structural brain imaging, electrophysiology, cellular and molecular neurobiology, genetics, lesion-based approaches, and computational modeling. All articles must relate to human language and be relevant to the understanding of its neurobiological and neurocognitive bases. Published articles in the journal are expected to have significant theoretical novelty and/or practical implications, and use perspectives and methods from psychology, linguistics, and neuroscience along with brain data and brain measures.