Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model.

Physical activity and nutrition Pub Date : 2023-03-01 DOI:10.20463/pan.2023.0001

Kibong Kim, Kang Pa Lee, Suji Beak, Sunyoung Park, Jisu Kim, Sang Hyun Ahn

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Abstract

Purpose: Excessive exercise causes various gastric dysfunction. Gastritis is common among athletes who perform high-intensity training. Gastritis is a digestive disease involving mucosal damage caused by inflammatory reactions and oxidative stress. In this study, the effects of a complex natural extract on gastric mucosal damage and the expression of inflammatory factors were evaluated in an animal model of alcohol-induced gastritis.

Methods: A mixed herbal medicine (Ma-al-gan; MAG) was prepared with four natural products (Curcumae longae Rhizoma, Schisandrae chinensis Fructus, Artemisiae scopariae herba, and Gardeniae Fructus) identified by a systemic analysis using the Traditional Chinese Medicine Systems Pharmacology platform. The effects of MAG on alcohol-induced gastric damage were evaluated.

Results: MAG (10-100 μg/mL) significantly reduced the mRNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells. MAG (500 mg/kg/d) effectively prevented alcohol-induced gastric mucosal injury in vivo.

Conclusion: MAG regulates inflammatory signals and oxidative stress and is a potential herbal medicine for gastric disorders.

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混合草药改善酒精性胃炎模型胃功能的可行性。

目的:过度运动引起各种胃功能障碍。胃炎在进行高强度训练的运动员中很常见。胃炎是一种消化道疾病，涉及炎症反应和氧化应激引起的粘膜损伤。本研究在酒精性胃炎动物模型中，评估了一种复杂的天然提取物对胃粘膜损伤和炎症因子表达的影响。方法:复方中药(麻辣干;MAG)由姜黄、五味子、蒿属和栀子四种天然产物组成，采用中药系统药理学平台进行系统分析。评价MAG对酒精性胃损伤的影响。结果:MAG (10 ~ 100 μg/mL)显著降低脂多糖刺激RAW264.7细胞诱导型一氧化氮合酶和环氧合酶-2 mRNA和蛋白水平。MAG (500 mg/kg/d)对体内酒精性胃黏膜损伤有明显的预防作用。结论:MAG调节炎症信号和氧化应激，是一种潜在的治疗胃疾病的草药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physical activity and nutrition

CiteScore

2.00

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0.00%

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