Effect of Different Classes of Antihypertensive Drugs on Arterial Stiffness.

IF 3.9 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reports Pub Date : 2023-05-01 DOI:10.1007/s11906-023-01238-4

Isabella Viana Gomes Schettini, Danyelle Romana Alves Rios, Roberta Carvalho Figueiredo

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引用次数: 1

Abstract

Purpose of review: To describe the physiological aspects of blood pressure and arterial stiffness, as well as explain how these processes are related. To review the available evidence on the effect of treatment with different classes of antihypertensive drugs on improving arterial stiffness.

Recent findings: Specific classes of antihypertensive drugs may have effects directly on improving arterial stiffness independent of lowering blood pressure. The maintenance of normal blood pressure levels is essential for the homeostasis of the whole organism; the increase in blood pressure is directly related to the increased risk of cardiovascular diseases. Hypertension is characterized by structural and functional changes in blood vessels and is associated with a more accelerated progression of arterial stiffness. Randomized clinical trials have shown that some specific classes of antihypertensive drugs can improve arterial stiffness independently of their effect on lowering brachial blood pressure. These studies show that calcium channel blockers (CCBs), angiotensin II receptor blockers (ARBs), and angiotensin-converting enzyme (ACE) inhibitors have been shown to have a better effect on arterial stiffness compared to diuretics and beta-blockers in individuals with arterial hypertension and other cardiovascular risk factors. More real-world studies are needed to assess whether this effect on arterial stiffness can improve the prognosis of patients with hypertension.

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不同类型降压药对动脉硬化的影响。

综述的目的:描述血压和动脉僵硬的生理方面，以及解释这些过程是如何相关的。综述不同类型降压药治疗对改善动脉硬化的影响。最近的发现:特定类别的抗高血压药物可能对改善动脉僵硬有直接作用，而不是降低血压。维持正常的血压水平对整个机体的内稳态至关重要;血压升高与心血管疾病的风险增加直接相关。高血压的特点是血管的结构和功能改变，并与动脉僵硬的加速进展有关。随机临床试验表明，一些特定类别的降压药可以改善动脉僵硬，而不依赖于其降低肱血压的作用。这些研究表明，钙通道阻滞剂(CCBs)、血管紧张素II受体阻滞剂(ARBs)和血管紧张素转换酶(ACE)抑制剂对动脉硬化的影响优于利尿剂和受体阻滞剂，适用于有动脉高血压和其他心血管危险因素的患者。需要更多的实际研究来评估这种对动脉硬度的影响是否可以改善高血压患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Hypertension Reports 医学-外周血管病

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.